C
Cheryl L. Paul
Researcher at Royal Prince Alfred Hospital
Publications - 16
Citations - 6603
Cheryl L. Paul is an academic researcher from Royal Prince Alfred Hospital. The author has contributed to research in topics: DNA methylation & GSTP1. The author has an hindex of 11, co-authored 16 publications receiving 6337 citations. Previous affiliations of Cheryl L. Paul include Garvan Institute of Medical Research & Commonwealth Scientific and Industrial Research Organisation.
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Journal ArticleDOI
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.
Marianne Frommer,Louise E. McDonald,Douglas Spencer Millar,Christina M. Collis,Fujiko Watt,Geoffrey W. Grigg,Peter L. Molloy,Cheryl L. Paul +7 more
TL;DR: A genomic sequencing method is reported that provides positive identification of 5-methylcytosine residues and yields strand-specific sequences of individual molecules in genomic DNA, which suggests that the high methylation level of single-copy sequences in sperm may be locally modulated by binding of protein factors in germ-line cells.
Journal ArticleDOI
High sensitivity mapping of methylated cytosines.
TL;DR: A genomic sequencing technique which is capable of detecting every methylated cytosine on both strands of any target sequence, using DNA isolated from fewer than 100 cells is developed.
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Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA
Peter M. Warnecke,Clare Stirzaker,John R. Melki,Douglas Spencer Millar,Cheryl L. Paul,Susan J. Clark,Susan J. Clark +6 more
TL;DR: This study presents a simple method for detection and measurement of PCR bias for any set of primers, and investigates parameters for overcoming PCR bias.
Journal Article
Extensive DNA Methylation Spanning the Rb Promoter in Retinoblastoma Tumors
Clare Stirzaker,Douglas Spencer Millar,Cheryl L. Paul,Peter M. Warnecke,Janet Harrison,Paul C. Vincent,Marianne Frommer,Susan J. Clark +7 more
TL;DR: The dynamics of DNA methylation in cancer cells are clearly different from normal cells and an insight into the mechanism of abnormal methylation of CpG islands incancer cells is given.
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Detailed methylation analysis of the glutathione S-transferase π (GSTP1) gene in prostate cancer
Douglas Spencer Millar,Kim K Ow,Cheryl L. Paul,Pamela J. Russell,Peter L. Molloy,Susan J. Clark,Susan J. Clark +6 more
TL;DR: Analysis of methylation at 131 CpG sites spanning the promoter and body of the GSTP1 gene found that both alleles are abnormally methylated in this region, and in normal prostate tissue, the entire C pG island was unmethylated, but extensive methylation was found outside the island in the body ofthe gene.