The therapeutic journey of benzimidazoles: a review.

1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. In this study, an attempt has been made with recent research findings on this nucleus, to review the structural modifications on different thiadiazole derivatives for various pharmacological activities.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.12125

1,3,4-thiadiazole and its derivatives: a review on recent progress in biological activities.

The properties of benzimidazole and its derivatives have been studied over more than one hundred years. Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. This work systematically gives a comprehensive review in current developments of benzimidazole-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents. This review will further be helpful for the researcher on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimidazole drugs/compounds.

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.

Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents

Use of mixed dyes in a photogalvanic cell for solar energy conversion and storage: EDTA–thionine–azur-B system

A number of 1N-substituted-2-methyl benzimidazole derivatives have been synthesized and tested for their antibacterial activities. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analyses. Investigation of antimicrobial activity of the compounds was done by disc diffusion method using Gram-positive (S. aureus, S. mutans and B. subtilis), Gram-negative (E. coli, S. typhi and P. aeruginosa) bacteria and fungi (C. albicans, A. flavus and A. niger). Among the compounds tested 5a, 5b, 5d, 5i, 5j and 5k exhibited good antibacterial activities against Gram positive bacteria, while 5d and 5i also showed notable antifungal activity. Specially compounds 5a and 5b exhibited appreciable activity against S. aureus and B. subtilis comparable to reference drugs.

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Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety

Photogalvanic effects were studied in a photogalvanic cell containing toluidine blue, glucose and tergitol-7 as a photosensitizer, reductant and surfactant, respectively. The photocurrent and photopotential generated by this system were 70 μA and 315 mV, respectively. The effects of different parameters on the electrical output of the cell were observed. Current/voltage characteristics of the cell have also been studied, and a mechanism has been proposed for the generation of photocurrent in photogalvanic cell.

Chhagan Lal

Papers

Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents

Use of mixed dyes in a photogalvanic cell for solar energy conversion and storage: EDTA–thionine–azur-B system

Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety

Use of tergitol‐7 in photogalvanic cell for solar energy conversion and storage: Toluidine blue‐glucose system