H
Heidi Galonek
Publications - 3
Citations - 1956
Heidi Galonek is an academic researcher. The author has contributed to research in topics: Sirtuin 1 & Calorie restriction. The author has an hindex of 3, co-authored 3 publications receiving 1819 citations.
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Journal ArticleDOI
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne,Philip D. Lambert,Simon Schenk,David P. Carney,J. Joshua Smith,David J. Gagne,Lei Jin,Olivier Boss,Robert B. Perni,Chi B. Vu,Jean Bemis,Roger Xie,Jeremy S. Disch,Pui Yee Ng,Joseph J. Nunes,Amy V. Lynch,Hongying Yang,Heidi Galonek,Kristine Israelian,Wendy Choy,Andre Iffland,Siva Lavu,Oliver Medvedik,David A. Sinclair,Jerrold M. Olefsky,Michael R. Jirousek,Peter J. Elliott,Christoph H. Westphal +27 more
TL;DR: These compounds bind to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates and improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.
Journal ArticleDOI
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
J. Joshua Smith,Renee Deehan Kenney,David J. Gagne,Brian P. Frushour,William M. Ladd,Heidi Galonek,Kristine Israelian,Jeffrey Song,Giedre Razvadauskaite,Amy V. Lynch,David P. Carney,Robin J Johnson,Siva Lavu,Andre Iffland,Peter J. Elliott,Philip D. Lambert,Keith O. Elliston,Michael R. Jirousek,Jill C. Milne,Olivier Boss +19 more
TL;DR: It is demonstrated that SIRT1 activators recapitulate many of the molecular events downstream of CR in vivo, such as enhancing mitochondrial biogenesis, improving metabolic signaling pathways, and blunting pro-inflammatory pathways in mice fed a high fat, high calorie diet.
Journal ArticleDOI
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3
Lei Jin,Heidi Galonek,Kristine Israelian,Wendy Choy,Michael Morrison,Yu Xia,Xiaohong Wang,Yihua Xu,Yuecheng Yang,J. Joshua Smith,Ethan Hoffmann,David P. Carney,Robert B. Perni,Michael R. Jirousek,Jean Bemis,Jill C. Milne,David A. Sinclair,Christoph H. Westphal +17 more
TL;DR: It is demonstrated that SIRT3 has no deacetylation activity in vitro unless the protein is truncated, consistent with human SIRT2, and the inhibition constants and mechanism of action for nicotinamide and a small molecule Sirt3 inhibitor against active mouse SIRT1 and NAD+.