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Chi Bun Chan
Researcher at University of Hong Kong
Publications - 83
Citations - 3557
Chi Bun Chan is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Receptor & Kinase. The author has an hindex of 31, co-authored 72 publications receiving 3028 citations. Previous affiliations of Chi Bun Chan include Emory University & University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
Christina Gross,Mika Nakamoto,Xiaodi Yao,Chi Bun Chan,So Y. Yim,Keqiang Ye,Stephen T. Warren,Gary J. Bassell +7 more
TL;DR: It is shown that deficiency of FMRP results in excess activity of phosphoinositide 3-kinase (PI3K), a downstream signaling molecule of many cell surface receptors that suggests that dysregulated PI3K signaling may underlie the synaptic impairments in FXS.
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A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
Xia Liu,Chi Bun Chan,Sung-Wuk Jang,Sompol Pradoldej,Junjian Huang,Kunyan He,Lien H. Phun,Ge Xiao,Yonghui Jia,Hongbo R. Luo,Keqiang Ye +10 more
TL;DR: The data support that the synthetic 4'-dimethylamino-7,8-dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent antidepressant effects.
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7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.
Zhentao Zhang,Xia Liu,Jason P. Schroeder,Chi Bun Chan,Mingke Song,Shan Ping Yu,David Weinshenker,Keqiang Ye +7 more
TL;DR: Results suggest that 7,8-DHF represents a novel oral bioactive therapeutic agent for treating AD and inhibited the loss of hippocampal synapses, restored synapse number and synaptic plasticity, and prevented memory deficits.
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Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli.
TL;DR: The first report on the identification of a GHSR-1b transcript from species other than mammals is reported and the demonstration that receptor interaction might provide a possible explanation for the existence and biological significance of the sbGHSR 1b transcript is demonstrated.
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The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor.
Po Ki Leung,Kevin B.S. Chow,Pui Ngan Lau,Kit Man Chu,Chi Bun Chan,Christopher H.K. Cheng,Helen Wise +6 more
TL;DR: GHS-R1b appears to act as a dominant-negative mutant of the full-length ghrelin receptor, and it is proposed that the decrease in GRLN-R constitutive signalling was due to translocation of GRLn-R to the nucleus due to the formation of GRS-R/G HS-R 1b heterodimers.