Showing papers in "Cellular Signalling in 2007"

TL;DR: This review summarizes current studies that have been regarding the production of ROS and the general redox-sensitive targets of cell signalling cascades.

TL;DR: Improvements have been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response.

TL;DR: In this paper, a review of the current understanding concerning the association of HOCl and neuronal cell death is presented, where the authors conclude that HOCl is a major oxidant produced by activated phagocytes in the presence of myeloperoxidase.

TL;DR: It is shown that RIP3 is cleaved at Asp328 by caspase-8 under apoptotic stimuli, which is blocked by pan-caspase inhibitor Z-VAD-FMK, and the cleaved product of RIP3 (aa 329-518) displays better stability than wild type RIP3.

TL;DR: Each of the above mentioned mechanisms will be discussed, as a detailed molecular and genetic understanding of how EGFR contributes to the malignant phenotype might offer new promise for the design, development and clinical evaluation of future tumor-specific anticancer approaches.

TL;DR: This review highlights recent progress in the understanding of the multiplicity of Wnts and their receptors and discusses how the interaction between the ligands and receptors activate distinct intracellular signaling pathways.

TL;DR: A better understanding of the mechanism underlying STAT1 regulation of cell death may lead to successful strategies for targeting STAT1 in such pathological settings.

TL;DR: It is demonstrated that FAK and AKT are independently regulated by early activation of SMAD3 and p38 MAPK, respectively, which contributes to essential roles of TGF-beta1 in tissue fibrosis and tumour-promotion.

TL;DR: Two-dimensional phosphopeptide mapping using mutation of phosphorylation sites for MAPK revealed that the nine serine residues in Foxo1 are specifically phosphorylated by Erk and p38, and that this phosphorylations regulates the function of Foxo 1 as a coactivator for Ets-1.

TL;DR: Findings reveal for the first time that TNF stimulation of adhesion molecules ICAM-1 and VCAM- 1 in human endothelial cells occurs through the TNFR1 subtype and is mediated by the NF-kappaB pathway, but not the ERK, p38MAPK or JNK kinase pathways.

TL;DR: It is found that AKT is the downstream target of PI3K in controllingAngiogenesis and tumor growth, and PTEN could inhibit angiogenesis by regulating the expression of HIF-1 and VEGF expression through AKT activation in PC-3 cells.

TL;DR: It is demonstrated that beta(2)ARs possess pro-inflammatory properties and that their activation leads to IL-1beta and IL-6 production through ERK1/2- and p38-dependent activation of ATF-1 and ATF-2 transcription factors.

TL;DR: Results indicate that the ROS-mediated TNF-α-induced IL-8 transcription is regulated by NF-κB/RelA phosphorylation at the critical Ser276 residue by PKAc, resulting in stable enhanceosome formation on target genes.

TL;DR: Taken together the SLR motif establishes a link between signal transduction pathways from eukaryotes and bacteria and could have developed in the last common ancestor between eukARYotes andacteria.

TL;DR: GHS-R1b appears to act as a dominant-negative mutant of the full-length ghrelin receptor, and it is proposed that the decrease in GRLN-R constitutive signalling was due to translocation of GRLn-R to the nucleus due to the formation of GRS-R/G HS-R 1b heterodimers.

TL;DR: Data is reviewed supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration.

TL;DR: The studies on the biochemical properties and the regulation of MKP-1 are updated, the understanding on the physiological function of this key phosphatase in the innate immune response is summarized.

TL;DR: A bioinformatic analysis of various segments of tribbles proteins is described, which has revealed a number of highly conserved peptide motifs with potentially important functional roles.

TL;DR: It is shown that Epo prevents staurosporine-induced apoptosis of differentiated human neuroblastoma SH-SY5Y cells, and activates the STAT5, AKT and MAPK signaling pathways.

TL;DR: This review focuses on the metabolic enzymes (acid and alkaline sphingomyelinases, neutral ceramidase, and sphingosine kinase) that are involved in the production of the sphingolipid metabolites in these extracellular spaces, and in the metabolic pathway itself.

TL;DR: An in vitro model of the intracellular signaling mechanisms activated by NE, via ligand-G-protein-coupled receptor (GPCR)-to-BDNF-RTK transactivation, that is putatively thought to occur in vivo as a result of excitatory neural activity is provided.

TL;DR: The present review will summarise the data on mechanotransduction in vascular smooth muscle cells and formulate a new hypothesis, i.e. a non-specific activation of mechanoceptors followed by a variety of signal cascade activation, that could provide some clues for exploring new therapeutic targets for the disturbed mechanical stress-initiated diseases such as hypertension and atherosclerosis.

TL;DR: This review focuses on how PKCe collaborates with other signaling pathways, such as Ras/Raf/ERK and Akt, to regulate cell survival and cell death and how it mediates its antiapoptotic signal by altering the level or function of pro- and antiapopotic Bcl-2 family members.

TL;DR: It is shown that in small cell lung cancer (SCLC) cells, specific growth factor receptors such as c-Kit associate with lipid rafts and that these domains play a critical role in the activation of phosphoinositide 3-kinase (PI3K) signalling.

TL;DR: A role of ROS as key second messengers granting a proper executed mitosis for anchorage-dependent cells, through redox regulation of several downstream targets is supported.

TL;DR: The findings suggest that hD2R and hSSTR2 operate as functional heterodimers modulated by ligands in situ, which may prove to be a useful model in designing new therapeutic drugs.

TL;DR: Most recent data concerning TRP vanilloid (TRPV) type 6, TRP melastatin (TRPM) type 1 and 8 channels and their relevance for common human cancer types will be highlighted in this review.

TL;DR: Detailed insights are provided into the regulation of SPP2 gene expression and it is suggested thatSPP2 might be a novel player in pro-inflammatory signalling.

TL;DR: A novel signal transduction pathway for Shh is described, which is transcription/translation-independent, SuFu insensitive, and consequently independent of Gli-mediated induction of transcription, and might explain the developmental abnormalities observed in both patients with defective leukotriene metabolism and rodent models of defective Rho family GTPase signaling.

TL;DR: It is demonstrated that most Sin1 orthologues contain both a Raf-like Ras-binding domain (RBD) and a pleckstrin homology (PH) domain, which suggest that Sin1 is a mammalian Ras-inhibitor.