K
Keqiang Ye
Researcher at Emory University
Publications - 248
Citations - 16867
Keqiang Ye is an academic researcher from Emory University. The author has contributed to research in topics: Tropomyosin receptor kinase B & Protein kinase B. The author has an hindex of 64, co-authored 223 publications receiving 13761 citations. Previous affiliations of Keqiang Ye include Johns Hopkins University & Huazhong University of Science and Technology.
Papers
More filters
Journal ArticleDOI
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Bin Zhao,Xiaomu Wei,Weiquan Li,Ryan S. Udan,Ryan S. Udan,Qian Yang,Joungmok Kim,Joungmok Kim,Joe Xie,Tsuneo Ikenoue,Jindan Yu,Li Li,Li Li,Pan Zheng,Keqiang Ye,Arul M. Chinnaiyan,Georg Halder,Georg Halder,Zhi Chun Lai,Kun-Liang Guan,Kun-Liang Guan +20 more
TL;DR: It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
Journal ArticleDOI
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Sung-Wuk Jang,Xia Liu,Manuel Yepes,Kennie R. Shepherd,Gary W. Miller,Yang Liu,W. David Wilson,Ge Xiao,Bruno Blanchi,Yi E. Sun,Keqiang Ye +10 more
TL;DR: 7,8-dihydroxyflavone imitates BDNF and acts as a robust TrkB agonist, providing a powerful therapeutic tool for the treatment of various neurological diseases.
Journal ArticleDOI
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease
Zhentao Zhang,Mingke Song,Xia Liu,Seong Su Kang,Il Sun Kwon,Duc M. Duong,Nicholas T. Seyfried,William T. Hu,Zhixue Liu,Jian-Zhi Wang,Liming Cheng,Yi E. Sun,Shan Ping Yu,Allan I. Levey,Keqiang Ye +14 more
TL;DR: Asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is activated during aging and proteolytically degrades tau, abolishes its microtubule assembly function, induces tau aggregation and triggers neurodegeneration, indicating that AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.
Journal ArticleDOI
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo
Xianhe Bai,Francesca Cerimele,Masuko Ushio-Fukai,Muhammad Waqas,Paul M. Campbell,Baskaran Govindarajan,Channing J. Der,Traci E. Battle,David A. Frank,Keqiang Ye,Emma Murad,Wolfgang Dubiel,Gerald A. Soff,Jack L. Arbiser +13 more
TL;DR: The preclinical data suggests that honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent.
Journal ArticleDOI
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Taro Hitosugi,Lu Zhou,Shannon Elf,Jun Fan,Hee-Bum Kang,Jae Ho Seo,Changliang Shan,Qing Dai,Liang Zhang,Jianxin Xie,Ting-Lei Gu,Peng Jin,Maša Alečković,Gary LeRoy,Yibin Kang,Jessica Sudderth,Ralph J. DeBerardinis,Chi Hao Luan,Georgia Z. Chen,Susan Muller,Dong M. Shin,Taofeek K. Owonikoko,Sagar Lonial,Martha Arellano,Hanna Jean Khoury,Fadlo R. Khuri,Benjamin H. Lee,Keqiang Ye,Titus J. Boggon,Sumin Kang,Chuan He,Jing Chen +31 more
TL;DR: Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth.