C
Chien-Chih Chiu
Researcher at Kaohsiung Medical University
Publications - 171
Citations - 3916
Chien-Chih Chiu is an academic researcher from Kaohsiung Medical University. The author has contributed to research in topics: Apoptosis & Cancer. The author has an hindex of 33, co-authored 146 publications receiving 2942 citations. Previous affiliations of Chien-Chih Chiu include National Sun Yat-sen University & National Taiwan Normal University.
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Journal ArticleDOI
The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB
I-Ling Lin,Han-Lin Chou,Han-Lin Chou,Jin-Ching Lee,Feng-Wei Chen,Yao Fong,Wei Chiao Chang,Hurng-Wern Huang,Chang-Yi Wu,Wen-Tsan Chang,Hui-Min David Wang,Chien-Chih Chiu +11 more
TL;DR: Results indicated the antiproliferative effect of C2-ceramide is majorly responsible for cell apoptosis in lung cancer H1299 cells.
Journal ArticleDOI
4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest
Ching Yu Yen,Chien-Chih Chiu,Fang Rong Chang,Jeff Yi-Fu Chen,Chi Ching Hwang,You-Cheng Hseu,Hsin-Ling Yang,Alan Yueh-Luen Lee,Ming Tz Tsai,Zong Lun Guo,Yu Shan Cheng,Yin Chang Liu,Yu-Hsuan Lan,Yu Ching Chang,Ying-Chin Ko,Ying-Chin Ko,Hsueh-Wei Chang,Yang Chang Wu +17 more
TL;DR: It is demonstrated that golden berry-derived 4βHWE is a potential DNA-damaging and chemotherapeutic agent against lung cancer.
Journal ArticleDOI
Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways.
Chien-Chih Chiu,Jo Wen Haung,Fang Rong Chang,Kuang Jing Huang,Hsuan Min Huang,Hurng-Wern Huang,Chon-Kit Chou,Yang Chang Wu,Yang Chang Wu,Hsueh-Wei Chang +9 more
TL;DR: The findings of this study, particularly the improved understanding of the selective killing mechanisms of 4βHWE, can be used to improve efficiency in killing oral cancer cells during chemoprevention and therapy.
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Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment.
Sheng-Kai Hsu,Chia-Yang Li,I-Ling Lin,Wun-Jyun Syue,Yih Fung Chen,Kai-Chun Cheng,Yen-Ni Teng,Yi-Hsiung Lin,Chia-Hung Yen,Chien-Chih Chiu +9 more
TL;DR: In this paper, the role of pyroptosis in cancer progression and the modulation of immunity is discussed, and the potential small molecules and nanomaterials that target pyroptic cell death mechanisms and their therapeutic effects on cancer are summarized.
Journal ArticleDOI
Resistin facilitates breast cancer progression via TLR4- mediated induction of mesenchymal phenotypes and stemness properties
C. H. Wang,P. J. Wang,Ya-Ching Hsieh,Steven Lo,Steven Lo,Yi Chen Lee,Yuk-Kwan Chen,Chun-Hao Tsai,W. C. Chiu,S. Chu Sung Hu,C. W. Lu,Y. F. Yang,Chien-Chih Chiu,F. Ou-Yang,Yun-Ming Wang,Yun-Ming Wang,Ming-Feng Hou,Shyng-Shiou F. Yuan +17 more
TL;DR: It is observed that high serum resistin levels in breast cancer patients positively correlated with tumor stage, size and lymph node metastasis, and this findings provide clear evidence that resistin is a clinically relevant endogenous ligand forTLR4, which promotes tumor progression via TLR4/NF-κB/STAT3 signaling.