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Chih Chen Hong
Researcher at National Health Research Institutes
Publications - 16
Citations - 804
Chih Chen Hong is an academic researcher from National Health Research Institutes. The author has contributed to research in topics: Metastasis & Cancer cell. The author has an hindex of 12, co-authored 15 publications receiving 709 citations. Previous affiliations of Chih Chen Hong include China Medical University (Taiwan).
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Journal ArticleDOI
The role of the VEGF-C/VEGFR-3 axis in cancer progression
Jen Liang Su,C.-J. Yen,Pai Sheng Chen,Shuang En Chuang,Chih Chen Hong,I. H. Kuo,H. Y. Chen,Mien Chie Hung,Min-Liang Kuo +8 more
TL;DR: The novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression is discussed, which enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis.
Journal ArticleDOI
CTGF enhances the motility of breast cancer cells via an integrin-αvβ3-ERK1/2-dependent S100A4-upregulated pathway
Pai Sheng Chen,Ming-Yang Wang,Shin Ni Wu,Jen Liang Su,Chih Chen Hong,Shuang En Chuang,Min Wei Chen,Kuo Tai Hua,Yu Ling Wu,Shih-Ting Cha,Munisamy Suresh Babu,Chiung-Nien Chen,Po-Huang Lee,King-Jen Chang,Min-Liang Kuo +14 more
TL;DR: It is concluded that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-αvβ3–ERK1/2–S100A4 pathway.
Journal ArticleDOI
Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells
Jen Liang Su,Ming-Tsan Lin,Chih Chen Hong,Cheng-Chi Chang,Shine-Gwo Shiah,Cheng-Wen Wu,Szu-Ta Chen,Yat Pang Chau,Min-Liang Kuo +8 more
TL;DR: The possible involvement of apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase/FasL signaling cascade signaling in the regulation of FasL expression and subsequent apoptosis induced by resveratrol in HL-60 cells is suggested.
Journal ArticleDOI
Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility
Tsang Chih Kuo,Ching-Ting Tan,Yi Wen Chang,Yi Wen Chang,Chih Chen Hong,Wei Jiunn Lee,Min Wei Chen,Yung-Ming Jeng,Jean Chiou,Pei Yu,Pai Sheng Chen,Ming-Yang Wang,Michael Hsiao,Jen Liang Su,Min-Liang Kuo +14 more
TL;DR: It is demonstrated that ANGPTL1 represses lung cancer cell motility by abrogating the expression of the EMT mediator SLUG.
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The Role of the VEGF-C/VEGFRs Axis in Tumor Progression and Therapy
TL;DR: High levels of VEGF-C expression and VEGf-C/VEGFRs signaling correlate significantly with poorer prognosis in a variety of malignancies, therefore, the development of new drugs that selectively target the VEGFs/vegFRs axis seems to be an effective means to potentiate anti-tumor therapies in the future.