C
Chih Cheng Lee
Researcher at University of California, San Francisco
Publications - 7
Citations - 597
Chih Cheng Lee is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Stroke & Traumatic brain injury. The author has an hindex of 6, co-authored 6 publications receiving 487 citations. Previous affiliations of Chih Cheng Lee include United States Department of Veterans Affairs & San Francisco VA Medical Center.
Papers
More filters
Journal ArticleDOI
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.
Jialing Liu,Yongting Wang,Yosuke Akamatsu,Chih Cheng Lee,R. Anne Stetler,Michael T. Lawton,Guo-Yuan Yang +6 more
TL;DR: In this paper, the early phase of cerebral blood volume (CBV) increase is likely due to the improvement in collateral flow, also known as arteriogenesis, whereas the late phase of CBV increase is attributed to the surge of angiogenesis.
Journal ArticleDOI
CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.
Christine L. Hsieh,Eréne C. Niemi,Sarah H. Wang,Chih Cheng Lee,Deborah Bingham,Jiasheng Zhang,Myrna L. Cozen,Israel F. Charo,Eric J. Huang,Jialing Liu,Mary C. Nakamura +10 more
TL;DR: Results suggest that therapeutic blockade of CCR2-dependent responses may improve outcomes following TBI, and demonstrate that Ccr2 directs the majority of macrophage homing to the brain early after TBI and indicates that CCr2 may facilitate harmful responses.
Journal ArticleDOI
Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway.
Chongran Sun,Hui Sun,Hui Sun,Hui Sun,Steven Wu,Steven Wu,Chih Cheng Lee,Chih Cheng Lee,Yosuke Akamatsu,Yosuke Akamatsu,Yosuke Akamatsu,Ruikang K. Wang,Steven G. Kernie,Jialing Liu,Jialing Liu +14 more
TL;DR: Transgenic stroke mice treated with GCV displayed impaired spatial learning and memory in the Barnes maze test compared with saline control or wild-type stroke mice given GCV, suggesting a contributing role of stroke-induced neurogenesis in the recovery of cognitive function.
Journal ArticleDOI
Impaired leptomeningeal collateral flow contributes to the poor outcome following experimental stroke in the Type 2 diabetic mice
Yosuke Akamatsu,Yasuo Nishijima,Chih Cheng Lee,Shih Yen Yang,Lei Shi,Lin An,Ruikang K. Wang,Teiji Tominaga,Jialing Liu +8 more
TL;DR: The results suggest that the impaired collateral status contributes to the exacerbated ischemic injury in mice with Type 2 diabetes, and modulation of collateral flow has beneficial effects on stroke outcome among these subjects.
Journal ArticleDOI
Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury.
Tina I. Lam,Deborah Bingham,Deborah Bingham,Ting Ju Chang,Ting Ju Chang,Chih Cheng Lee,Chih Cheng Lee,Jian Shi,Jian Shi,Dongmin Wang,Dongmin Wang,Stephen M. Massa,Stephen M. Massa,Raymond A. Swanson,Raymond A. Swanson,Jialing Liu,Jialing Liu +16 more
TL;DR: Data provided a rationale for incorporating anti-inflammatory treatment during rehabilitation therapy and significantly reduced impairments of spatial learning and memory in the water maze test, whereas botox/physical therapy reduced forelimb motor asymmetry and improved manual dexterity in the cylinder and vermicelli handling tests.