E
Eric J. Huang
Researcher at University of California, San Francisco
Publications - 229
Citations - 26087
Eric J. Huang is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Neurodegeneration & Medicine. The author has an hindex of 72, co-authored 201 publications receiving 22172 citations. Previous affiliations of Eric J. Huang include Cornell University & Memorial Sloan Kettering Cancer Center.
Papers
More filters
Journal ArticleDOI
Neurotrophins: roles in neuronal development and function.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.
Journal ArticleDOI
Trk receptors: roles in neuronal signal transduction.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: The most fascinating aspect of Trk receptor-mediated signaling is its interplay with signaling promoted by the pan-neurotrophin receptor p75NTR, which activates a distinct set of signaling pathways within cells that are in some instances synergistic and in other instances antagonistic to those activated by Trk receptors.
Journal ArticleDOI
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.
Eric J. Huang,Karl Nocka,David R. Beier,Tang-Yan Chu,Jochen Buck,Hans-Werner Lahm,Daniel Wellner,Philip Leder,Peter Besmer +8 more
TL;DR: K, a hematopoietic growth factor obtained from conditioned medium of BALB/c 3T3 fibroblasts that stimulates the proliferation of mast cells and early erythroid progenitors, specifically binds to the c-kit receptor.
Journal ArticleDOI
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Shawn F. Sorrells,Mercedes F. Paredes,Arantxa Cebrián-Silla,Kadellyn Sandoval,Dashi Qi,Kevin W. Kelley,David James,Simone Mayer,Julia W. Chang,Kurtis I. Auguste,Edward F. Chang,Antonio Gutierrez,Arnold R. Kriegstein,Gary W. Mathern,Michael C. Oldham,Eric J. Huang,José Manuel García-Verdugo,Zhengang Yang,Arturo Alvarez-Buylla +18 more
TL;DR: It is shown that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans.
Journal ArticleDOI
Corridors of migrating neurons in the human brain and their decline during infancy
Nader Sanai,Thuhien Nguyen,Rebecca A. Ihrie,Zaman Mirzadeh,Zaman Mirzadeh,Hui-Hsin Tsai,Michael Wong,Nalin Gupta,Mitchel S. Berger,Eric J. Huang,José Manuel García-Verdugo,David H. Rowitch,Arturo Alvarez-Buylla +12 more
TL;DR: It is found that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood.