C
Chih-Hsien Lee
Researcher at Chung Yuan Christian University
Publications - 14
Citations - 1023
Chih-Hsien Lee is an academic researcher from Chung Yuan Christian University. The author has contributed to research in topics: Nanoclusters & Microbubbles. The author has an hindex of 7, co-authored 14 publications receiving 948 citations.
Papers
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Journal ArticleDOI
Synthesis, Characterization, and Bioconjugation of Fluorescent Gold Nanoclusters toward Biological Labeling Applications
Cheng-An J. Lin,Ting-Ya Yang,Chih-Hsien Lee,Sherry H. Huang,Ralph A. Sperling,Marco Zanella,Jimmy K. Li,Ji-Lin Shen,Hsueh-Hsiao Wang,Hung-I Yeh,Wolfgang J. Parak,Walter H. Chang +11 more
TL;DR: Synthesis of ultrasmall water-soluble fluorescent gold nanoclusters has a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules.
Journal ArticleDOI
Fluorescent gold nanoclusters as a biocompatible marker for in vitro and in vivo tracking of endothelial cells.
Hsueh-Hsiao Wang,Cheng-An J. Lin,Chih-Hsien Lee,Yi-Chun Lin,Ya-Ming Tseng,Chin-Ling Hsieh,Chih Hao Chen,Cheng-Ho Tsai,Chun-Tai Hsieh,Ji-Lin Shen,Wen-Hsiung Chan,Walter H. Chang,Hung-I Yeh,Hung-I Yeh +13 more
TL;DR: In vivo study using hindlimb ischemic mice with an intramuscular injection of FANC-labeled human EPC showed that the cells preserved an angiogenic potential and exhibited traceable signals after 21 days, demonstrating that FANC is a promising biocompatible fluorescent probe.
Synthesis of Fluorescent Metallic Nanoclusters toward Biomedical Application: Recent Progress and Present Challenges
J. Cheng-an Lin,Chih-Hsien Lee,Jyun-tai Hsieh,Hsueh-Hsiao Wang,Jimmy K. Li,Ji-Lin Shen,Wen-Hsiung Chan,Hung-I Yeh,Walter H. Chang +8 more
TL;DR: In this review, a new class of fluorescent labels by biocognition molecules to fluorescent noble-metal nanoclusters such as Au and Ag are produced, which are more biocompatible and stable against photobleaching compared with organic dyes and are ideal fluorophores for multicolor and multiplexing applications in biomedical engineering and molecular biotechnology.
Journal ArticleDOI
Application of Gold in Biomedicine: Past, Present and Future
Hsueh-Hsiao Wang,Hsueh-Hsiao Wang,Cheng-Huang Su,Yih-Jer Wu,Yih-Jer Wu,Cheng-An J. Lin,Chih-Hsien Lee,Ji-Lin Shen,Wen-Hsiung Chan,Walter H. Chang,Hung-I Yeh,Hung-I Yeh +11 more
TL;DR: F fluorescent gold nanoclusters (FANCs) are developed that contain gold nanoparticles with a core dimension in vitro and in vivo tracking of endothelial and endothelial progenitor cells and may also have novel chemical properties involved in regulation of endothelium cell function.
Patent
Fluorescent Gold Nanocluster and Method for Forming the Same
Walter H. Chang,Cheng-An Lin,Ting-Ya Yang,Chih-Hsien Lee,Ralph A. Sperling,Wolfgang J. Parak +5 more
TL;DR: In this paper, a fluorescent gold nanocluster, comprising of a dihydrolipoic acid ligand (DHLA) on the surface thereof, was shown to generate fluorescence by the interaction between the DHLA and the nanocuster.