Wen-Hsiung Chan

TL;DR: In vivo study using hindlimb ischemic mice with an intramuscular injection of FANC-labeled human EPC showed that the cells preserved an angiogenic potential and exhibited traceable signals after 21 days, demonstrating that FANC is a promising biocompatible fluorescent probe.

TL;DR: It is demonstrated that curcumin (Cur), the yellow pigment of Curcuma longa with known anti‐oxidant and anti‐inflammatory properties, can prevent UV irradiation‐induced apoptotic changes, including c‐Jun N‐terminal kinase (JNK) activation, loss of mitochondrial membrane potential (MMP), mitochondrial release of cytochrome C, caspase‐3 activation, and cleavage/activation of PAK2 in A431 cells.

TL;DR: The hypothesis that curcumin inhibits MG‐induced apoptosis in mouse ESC‐B5 cells and blastocysts by blocking ROS formation and subsequent apoptotic biochemical events is supported.

TL;DR: In this review, a new class of fluorescent labels by biocognition molecules to fluorescent noble-metal nanoclusters such as Au and Ag are produced, which are more biocompatible and stable against photobleaching compared with organic dyes and are ideal fluorophores for multicolor and multiplexing applications in biomedical engineering and molecular biotechnology.

TL;DR: It is shown for the first time that MG treatment triggers apoptosis in osteoblasts via specific apoptotic signaling, and causes BMD loss in vivo.