C
Ching On Wong
Researcher at University of Texas at Austin
Publications - 34
Citations - 1675
Ching On Wong is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Transient receptor potential channel & Patch clamp. The author has an hindex of 22, co-authored 32 publications receiving 1344 citations. Previous affiliations of Ching On Wong include Rutgers University & University of Texas Health Science Center at Houston.
Papers
More filters
Journal ArticleDOI
Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling
Yong Zhou,Ching On Wong,Kwang Jin Cho,Dharini van der Hoeven,Hong Liang,Dhananiay P. Thakur,Jialie Luo,Milos Babic,Konrad E. Zinsmaier,Michael X. Zhu,Michael X. Zhu,Hongzhen Hu,Hongzhen Hu,Kartik Venkatachalam,Kartik Venkatachalam,John F. Hancock,John F. Hancock +16 more
TL;DR: It is shown that plasma membrane depolarization induces nanoscale reorganization of phosphatidylserine and phosphatinositol 4,5-bisphosphate but not other anionic phospholipids, and K-Ras nanoclusters set up the plasma membrane as a biological field-effect transistor, allowing membrane potential to control the gain in mitogenic signaling circuits.
Journal ArticleDOI
The Role of TRPMLs in Endolysosomal Trafficking and Function
TL;DR: The functional and biophysical properties of these enigmatic cation channels, which represent the most ancient and archetypical TRP channels, are reviewed.
Journal ArticleDOI
Heteromeric TRPV4-C1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells
Xin Ma,Kwong Tai Cheng,Ching On Wong,Ching On Wong,Roger G. O'Neil,Lutz Birnbaumer,Indu S. Ambudkar,Xiaoqiang Yao +7 more
TL;DR: It is suggested that an enhanced vesicular trafficking of heteromeric TRPV4-C1 channels contributes to SOCE in vascular endothelial cells and may play a role in thapsigargin-induced vascular relaxation in rat small mesenteric arteries.
Journal ArticleDOI
Functional Role of Vanilloid Transient Receptor Potential 4-Canonical Transient Receptor Potential 1 Complex in Flow-Induced Ca2+ Influx
Xin Ma,Shuang Qiu,Jianhong Luo,Yan Ma,Ching Yuen Ngai,Bing Shen,Ching On Wong,Yu Huang,Xiaoqiang Yao +8 more
TL;DR: This study shows that TRPC1 interacts physically with TRPV4 to form a complex, and this TRpV4-C1 complex may mediate flow-induced Ca2+ influx in vascular endothelial cells.
Journal ArticleDOI
Drosophila TRPML is required for TORC1 activation.
TL;DR: It is shown that TRPML was required for fusion of amphisomes with lysosomes, and its absence led to accumulation of vesicles of significantly larger volume and higher luminal Ca(2+) and the intriguing possibility that a high-protein diet might reduce the severity of MLIV.