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Xin Ma
Researcher at Jiangnan University
Publications - 90
Citations - 2560
Xin Ma is an academic researcher from Jiangnan University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 26, co-authored 85 publications receiving 2050 citations. Previous affiliations of Xin Ma include The Chinese University of Hong Kong.
Papers
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Journal ArticleDOI
Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance
Xin Ma,Zhen Chen,Dong Hua,Dongxu He,Linjun Wang,Peng Zhang,Junqi Wang,Yanfei Cai,Caiji Gao,Xiaodong Zhang,Fang-fang Zhang,Teng Wang,Tingting Hong,Linfang Jin,Xiaowei Qi,Shu-Xian Chen,Xiao-Ting Gu,Dangtong Yang,Qiongxi Pan,Yifei Zhu,Yun Chen,Daozhen Chen,Liwen Jiang,Xiaofeng Han,Yanyun Zhang,Jian Jin,Xiaoqiang Yao +26 more
TL;DR: It was found that drug-resistant adriamycin-resistant human breast cancer cells possessed numerous transient receptor potential channel 5 (TrpC5) -containing extracellular vesicles (EVs) on the cell surface that may transfer chemoresistance property to nonchemoresistant recipient cells.
Journal ArticleDOI
Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells
Xin Ma,Yanfei Cai,Yanfei Cai,Dongxu He,Chang Zou,Peng Zhang,Chun Yin Lo,Zhenyu Xu,Franky L. Chan,Shan Yu,Yun Chen,Yun Chen,Rui-Yu Zhu,Rui-Yu Zhu,Jianyong Lei,Jian Jin,Jian Jin,Xiaoqiang Yao +17 more
TL;DR: An essential role of TRPC5–NFATc3–P-gp signaling cascade in P-gp induction in drug-resistant cancer cells is demonstrated and it is demonstrated that suppressing TRPC 5 decreased the growth of tumor xenografts.
Journal ArticleDOI
Heteromeric TRPV4-C1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells
Xin Ma,Kwong Tai Cheng,Ching On Wong,Ching On Wong,Roger G. O'Neil,Lutz Birnbaumer,Indu S. Ambudkar,Xiaoqiang Yao +7 more
TL;DR: It is suggested that an enhanced vesicular trafficking of heteromeric TRPV4-C1 channels contributes to SOCE in vascular endothelial cells and may play a role in thapsigargin-induced vascular relaxation in rat small mesenteric arteries.
Journal ArticleDOI
Functional Role of Vanilloid Transient Receptor Potential 4-Canonical Transient Receptor Potential 1 Complex in Flow-Induced Ca2+ Influx
Xin Ma,Shuang Qiu,Jianhong Luo,Yan Ma,Ching Yuen Ngai,Bing Shen,Ching On Wong,Yu Huang,Xiaoqiang Yao +8 more
TL;DR: This study shows that TRPC1 interacts physically with TRPV4 to form a complex, and this TRpV4-C1 complex may mediate flow-induced Ca2+ influx in vascular endothelial cells.
Journal ArticleDOI
TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel
TL;DR: The first heteromeric TRP channels composed of subunits from 3 different TRP subfamilies are identified, mediates the flow‐induced Ca2+ increase in native vascular endothelial cells and contributes to the ion permeation pore of the channels.