C
Chris E. Cooper
Researcher at University of Essex
Publications - 269
Citations - 20126
Chris E. Cooper is an academic researcher from University of Essex. The author has contributed to research in topics: Cytochrome c oxidase & Hemoglobin. The author has an hindex of 62, co-authored 265 publications receiving 19096 citations. Previous affiliations of Chris E. Cooper include University College Hospital & University of Leicester.
Papers
More filters
Journal ArticleDOI
Nitric oxide synthases: structure, function and inhibition
TL;DR: This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in the authors' understanding of this enzyme family.
Journal ArticleDOI
Association between mitochondrial dysfunction and severity and outcome of septic shock
David Brealey,M. P. Brand,Iain P. Hargreaves,Simon J.R. Heales,John M. Land,Ryszard T. Smolenski,Nathan Davies,Chris E. Cooper,Mervyn Singer +8 more
TL;DR: In septic patients, an association between nitric oxide overproduction, antioxidant depletion, mitochondrial dysfunction, and decreased ATP concentrations that relate to organ failure and eventual outcome is found.
Journal ArticleDOI
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
Guy C. Brown,Chris E. Cooper +1 more
TL;DR: Nitric oxide reversibly inhibited oxygen consumption of brain synaptosomes and was apparently competitive with oxygen, suggesting that NO inhibition of cytochrome oxidase and the competion with oxygen may occur in vivo.
Journal ArticleDOI
The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: Chemical mechanism and physiological significance
Chris E. Cooper,Guy C. Brown +1 more
TL;DR: The chemistry of this inhibition by NO and CO is dependent on oxygen concentration, but that of HCN and H2S is not, and the enzyme may act as a physiological detoxifier of these gases.
Journal ArticleDOI
Performance comparison of several published tissue near-infrared spectroscopy algorithms
TL;DR: Multiwavelength near-infrared attenuation spectra on human forearm muscle, the adult rat head, and newborn piglet head are collected to compare the changes in chromophore concentration derived from these data using published algorithms from four groups, finding differences between the results from the algorithms on each data set.