C
Chriselle Mendonca
Researcher at Newcastle University
Publications - 3
Citations - 50
Chriselle Mendonca is an academic researcher from Newcastle University. The author has contributed to research in topics: Staphylococcus aureus & Escherichia coli. The author has an hindex of 2, co-authored 3 publications receiving 24 citations. Previous affiliations of Chriselle Mendonca include University of Dundee.
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Journal ArticleDOI
A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition.
Fatima R. Ulhuq,Margarida C. Gomes,Margarida C. Gomes,Gina Duggan,Gina Duggan,Manman Guo,Chriselle Mendonca,Grant Buchanan,James D. Chalmers,Zhenping Cao,Holger Kneuper,Sarah Murdoch,Sarah Thomson,Henrik Strahl,Matthias Trost,Matthias Trost,Serge Mostowy,Serge Mostowy,Tracy Palmer +18 more
TL;DR: It is shown that TspA has membrane-depolarizing activity and that S. aureus uses TSpA to inhibit the growth of a bacterial competitor in vivo, and that deletion of tspA leads to increased bacterial clearance.
Posted ContentDOI
A membrane-depolarising toxin substrate of the Staphylococcus aureus Type VII protein secretion system targets eukaryotes and bacteria
Fatima R. Ulhuq,Gina Duggan,Gina Duggan,Manman Guo,Chriselle Mendonca,Chriselle Mendonca,James D. Chalmers,Zhenping Cao,Holger Kneuper,Sarah Murdoch,Sarah Thomson,Henrik Strahl,Matthias Trost,Matthias Trost,Serge Mostowy,Serge Mostowy,Tracy Palmer,Tracy Palmer +17 more
TL;DR: In this article, an unbiased proteomic approach was used to identify TspA as a further T7SS substrate, encoded distantly from the T7ss gene cluster, is found across all S. aureus strains, and it has a toxic C-terminal domain that depolarizes membranes.
Posted ContentDOI
A membrane-depolarising toxin substrate of the Staphylococcus aureus Type VII secretion system mediates intra-species competition
Fatima R. Ulhuq,Margarida C. Gomes,Gina Duggan,Manman Guo,Chriselle Mendonca,Grant Buchanan,James D. Chalmers,Zhenping Cao,Holger Kneuper,Sarah Murdoch,Sarah Thomson,Henrik Strahl,Matthias Trost,Serge Mostowy,Tracy Palmer +14 more
TL;DR: This is the first T7SS substrate protein shown to have activity against both eukaryotes and prokaryotes, and TspA-dependent growth inhibition of RN6390 by strain COL in the zebrafish infection model, that is alleviated by the presence of TsaI homologues.