M
Margarida C. Gomes
Researcher at University of London
Publications - 10
Citations - 251
Margarida C. Gomes is an academic researcher from University of London. The author has contributed to research in topics: Zebrafish & Biology. The author has an hindex of 4, co-authored 6 publications receiving 115 citations. Previous affiliations of Margarida C. Gomes include Imperial College London.
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Journal ArticleDOI
The Case for Modeling Human Infection in Zebrafish
Margarida C. Gomes,Serge Mostowy +1 more
TL;DR: This work uses a variety of human pathogens to illuminate the versatility of the zebrafish infection model, revealing unexpected and important concepts underlying infectious disease.
Journal ArticleDOI
Possible role of L-form switching in recurrent urinary tract infection.
Katarzyna M. Mickiewicz,Yoshikazu Kawai,Lauren Drage,Margarida C. Gomes,Frances Davison,Robert Pickard,Judith Hall,Serge Mostowy,Phillip D. Aldridge,Jeff Errington +9 more
TL;DR: The results suggest that L-form switching is a physiologically relevant phenomenon that may contribute to the recurrence of infection in older patients with rUTI, and potentially other infections.
Journal ArticleDOI
A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition.
Fatima R. Ulhuq,Margarida C. Gomes,Margarida C. Gomes,Gina Duggan,Gina Duggan,Manman Guo,Chriselle Mendonca,Grant Buchanan,James D. Chalmers,Zhenping Cao,Holger Kneuper,Sarah Murdoch,Sarah Thomson,Henrik Strahl,Matthias Trost,Matthias Trost,Serge Mostowy,Serge Mostowy,Tracy Palmer +18 more
TL;DR: It is shown that TspA has membrane-depolarizing activity and that S. aureus uses TSpA to inhibit the growth of a bacterial competitor in vivo, and that deletion of tspA leads to increased bacterial clearance.
Journal ArticleDOI
Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection.
Alexandra R. Willis,Vincenzo Torraca,Margarida C. Gomes,Jennifer Shelley,Maria J. Mazon-Moya,Alain Filloux,Cristina Lo Celso,Cristina Lo Celso,Serge Mostowy,Serge Mostowy +9 more
TL;DR: Zebrafish infection can be used to capture Shigella-mediated stem cell-driven granulopoiesis and provide a new model system to study stem cell biology in vivo, and the results highlight the potential of manipulating stem cells to boost innate immunity and combat infectious disease.
Posted ContentDOI
A membrane-depolarising toxin substrate of the Staphylococcus aureus Type VII secretion system mediates intra-species competition
Fatima R. Ulhuq,Margarida C. Gomes,Gina Duggan,Manman Guo,Chriselle Mendonca,Grant Buchanan,James D. Chalmers,Zhenping Cao,Holger Kneuper,Sarah Murdoch,Sarah Thomson,Henrik Strahl,Matthias Trost,Serge Mostowy,Tracy Palmer +14 more
TL;DR: This is the first T7SS substrate protein shown to have activity against both eukaryotes and prokaryotes, and TspA-dependent growth inhibition of RN6390 by strain COL in the zebrafish infection model, that is alleviated by the presence of TsaI homologues.