C
Christel Buelens
Researcher at Université libre de Bruxelles
Publications - 12
Citations - 1336
Christel Buelens is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Dendritic cell & Interleukin 3. The author has an hindex of 9, co-authored 12 publications receiving 1322 citations. Previous affiliations of Christel Buelens include Free University of Brussels.
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Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway.
Valérie Verhasselt,Christel Buelens,Fabienne Willems,Donat De Groote,Nicole Haeffner-Cavaillon,Michel Goldman +5 more
TL;DR: The effects of graded doses of LPS on the cytokine profile, phenotype, and allostimulatory potential of human DC generated by culturing plastic-adherent PBMC in presence of IL-4 and granulocyte-macrophage-CSF are analyzed.
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Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells.
Christel Buelens,Fabienne Willems,Anne Delvaux,Géraldine Pierard,Jean Pierre Delville,Thierry Velu,Michel Goldman +6 more
TL;DR: It is concluded that the inhibitory effect of rIL‐10 on primary alloreactive T cell responses involves down‐regulation of class II MHC and B7‐2 expression at the DC surface.
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Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor
Christel Buelens,Valérie Verhasselt,Donat De Groote,Kris Thielemans,Michel Goldman,Fabienne Willems +5 more
TL;DR: It is concluded that IL‐10 prevents the generation of DC induced by GM‐CSF+IL‐4 and favors the development of macrophages with a lower T cell stimulatory potential, but secreting higher levels of IL‐8 than DC.
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Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10
Christel Buelens,Valérie Verhasselt,Donat De Groote,Kris Thielemans,Michel Goldman,Fabienne Willems +5 more
TL;DR: It is concluded that IL‐10 differentially influences LPS‐dependent and CD40‐dependent pathways of DC maturation, and inhibited IL‐12 production in both activation systems.
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Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties.
Christel Buelens,Emmanuel Bartholome,Zoulikha Amraoui,Michaël Boutriaux,Isabelle Salmon,Kris Thielemans,Fabienne Willems,Michel Goldman +7 more
TL;DR: It was concluded that monocytes cultured in the presence of IL-3 and IFN-beta differentiate into DCs with potent helper T-cell stimulatory capacity despite their low secretion of IL -12.