Christelle Guyot

TL;DR: It is suggested that the myofibroblast may represent a new important target of antitumor therapy because of its ability to interact with epithelial cells and other connective tissue cells and may thus control such phenomena as tumor invasion and angiogenesis.

TL;DR: Differences have been reported between these two fibrogenic cell populations, in the mechanisms leading to myofibroblastic differentiation, activation and "deactivation", but confirmation is required.

TL;DR: The results indicate that individual bile acids induce cell type-specific effects in a complex liver microenvironment, and the fact that PCLS support biliary epithelial cell and portal fibroblast proliferation will make this model very useful for the study of the mechanisms involved in portal fibrosis.

TL;DR: After CCl4 treatment, a proportion of myofibroblasts derived from hepatic stellate cells seems to dedifferentiate while in bile duct ligation model, myof fibrotic livers derived from portal fibroblast disappear by apoptosis, underlining the relevance of this model to evaluate the mechanisms involved in fibrotics liver remodelling.

TL;DR: It is shown here that common bile duct ligation represents an invaluable model to study myofibroblastic differentiation and extracellular matrix adaptation produced by an acute mechanical stress.