C
Christiaan B. Brink
Researcher at North-West University
Publications - 28
Citations - 758
Christiaan B. Brink is an academic researcher from North-West University. The author has contributed to research in topics: Cholinergic & Muscarinic acetylcholine receptor. The author has an hindex of 16, co-authored 27 publications receiving 672 citations. Previous affiliations of Christiaan B. Brink include Potchefstroom University for Christian Higher Education.
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Journal ArticleDOI
Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues.
Brian H. Harvey,Ingrid Duvenhage,Francois P. Viljoen,Nellie Scheepers,Sarel F. Malan,Sarel F. Malan,Gregers Wegener,Christiaan B. Brink,Jacobus P. Petzer +8 more
TL;DR: MB and MG present with structure-specific antidepressant-like effects following acute and sub-chronic treatment, possibly involving NOS and MAO-A inhibition and cortico-limbic 5HT and l-NE release.
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Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.
TL;DR: The results suggest that the antidepressant-like activity of PDE5 inhibitors involve alterations in monoaminergic neurotransmission, but involve a dependence on inherent cholinergic tone so that the final response is determined by the relative extent of activation of these systems.
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Tianeptine: A Novel Atypical Antidepressant that May Provide New Insights into the Biomolecular Basis of Depression
TL;DR: In reliable animal models of depression tianeptine has been shown to prevent neurodegeneration and decreases in hippocampal volume in response to chronic stress, and provides further support for the hypothesis that depression may involve dysregulation of pathways controlling cellular resilience and that treatment should be directed towards the reversal thereof.
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Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies.
TL;DR: It is reported that sildenafil increases muscarinic acetylcholine receptor (mAChR) signaling in human neuroblastoma cells, providing evidence for cholinergic-nitrergic interactions in the neurobiology of depression.
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Recent advances in drug action and therapeutics: Relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology
TL;DR: The understanding of molecular receptor and signal transduction pharmacology enables clinicians to improve their effective implementation of current and future pharmacotherapy, ultimately enhancing the quality of life of their patients.