Christian Putensen

TL;DR: It is indicated that maintaining spontaneous breathing during APRV requires less sedation and improves cardiopulmonary function, presumably by recruiting nonventilated lung units, requiring a shorter duration of ventilatory support and ICU stay.

TL;DR: One of the most important recommendations was that hypotension is not required to define shock, and as a result, importance is assigned to the presence of inadequate tissue perfusion on physical examination.

TL;DR: It is indicated that uncoupling of spontaneous and mechanical ventilation during APRV improves V A/Q matching in ARDS presumably by recruiting nonventilated lung units and PSV did not improve V A-Q distributions when compared with APRV without spontaneous breathing.

TL;DR: This review of randomized trial evidence for low tidal volume and high PEEP ventilation on mortality of patients with ARDS or acute lung injury found that trials were limited in number but showed mortality benefits with lower versus higher tidal volume.

TL;DR: ENHANCE provides supportive evidence for the favorable benefit/risk ratio observed in PROWESS and suggests that more effective use of drotrecogin alfa (activated) might be obtained by initiating therapy earlier.