C
Christian Sell
Researcher at Drexel University
Publications - 99
Citations - 15242
Christian Sell is an academic researcher from Drexel University. The author has contributed to research in topics: Senescence & Growth factor. The author has an hindex of 36, co-authored 96 publications receiving 13442 citations. Previous affiliations of Christian Sell include Lankenau Institute for Medical Research & Thomas Jefferson University.
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Journal ArticleDOI
53BP1 contributes to a robust genomic stability in human fibroblasts
Lauren S. Fink,Michaela Roell,Emanuela Caiazza,Chad A. Lerner,Thomas D. Stamato,Silvana Hrelia,Antonello Lorenzini,Christian Sell +7 more
TL;DR: A difference in the levels and recruitment of 53BP1 in mouse and human cells following DNA damage is demonstrated and evidence that unresolved DNA damage correlates with species lifespan is presented.
Journal Article
Effect of the myb gene product on expression of the PCNA gene in fibroblasts.
Salvatore Travali,Andres Ferber,Krzysztof Reiss,Christian Sell,J Koniecki,Bruno Calabretta,Renato Baserga +6 more
TL;DR: A constitutively expressed c-myb gene product confers to fibroblasts the ability of temporarily by-passing a ts block in the G1 phase of the cell cycle and the myb product, under these conditions, regulates the mRNA levels of PCNA and histone H3 either directly or indirectly by a post-transcriptional mechanism.
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Activated Ras Enhances Insulin-Like Growth Factor I Induction of Vascular Endothelial Growth Factor in Prostate Epithelial Cells
TL;DR: It is found that, in prostate epithelial cells, the introduction of an activated HRAS causes cells to produce VEGF in response to insulin-like growth factor I (IGF-I), and IGF-I produced locally for normal tissue homeostasis.
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DNA Damage Detection by 53BP1: Relationship to Species Longevity.
Eleonora Croco,Silvia Marchionni,Martine Bocchini,Cristina Angeloni,Thomas D. Stamato,Claudio Stefanelli,Silvana Hrelia,Christian Sell,Antonello Lorenzini +8 more
TL;DR: It is reported that cells from longer-lived species exhibit more tumor protein p53 binding protein 1 (53BP1) foci for a given degree of DNA damage relative to shorter-livedspecies, and it is proposed that the number of 53BP1 foci reflects the intrinsic capacity of cells to detect and respond to DNA harms.
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Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain.
TL;DR: In this article, the effects of insulin-like growth factor type 1 (IGF-I) on total protein oxidation in brain tissues and in cell cultures were studied. And the results indicate that in frontal cortex the level of oxidized proteins is significantly reduced in transgenic mice designed to overproduce IGF-I compared with wild-type animals.