C
Christian Sell
Researcher at Drexel University
Publications - 99
Citations - 15242
Christian Sell is an academic researcher from Drexel University. The author has contributed to research in topics: Senescence & Growth factor. The author has an hindex of 36, co-authored 96 publications receiving 13442 citations. Previous affiliations of Christian Sell include Lankenau Institute for Medical Research & Thomas Jefferson University.
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Book
Life-span extension : single-cell organisms to man
TL;DR: Exploiting Natural Variation in Life Span To Evaluate Mechanisms of Aging and Slow aging from An Exceptionally Long-Lived Rodent, the Naked Mole-Rat.
Book ChapterDOI
Mitochondrial Reactive Oxygen Species in Cellular Senescence
TL;DR: It is highlighted how mitochondrial ROS serves an initiating upstream, or sustaining downstream, role in the induction of senescence, and potential interventions to alleviate mitochondrial ROS and delay cellularsenescence are discussed.
Journal ArticleDOI
Development and Longevity: Cellular and Molecular Determinants - A Mini-Review.
TL;DR: The basis for the relationship between rate of development and longevity lies in adaptations that have occurred through evolution at multiple levels of biological complexity: organism, organ, cellular, and molecular.
Journal ArticleDOI
Insulin-like growth factor-I produced by seminal vesicles: relationship to intraepithelial basal cell hyperplasia in the prostate.
TL;DR: The results suggest that SVF is a local source of IGF-I that provides chronic stimulation of prostate cells that could contribute to the development of prostate cancer in older men.
Journal ArticleDOI
Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction.
TL;DR: It is found that both the methionine and rapamycin regimens delay or prevent activation of the senescence program in human cells, which suggests that senescent cells serve tissue‐specific roles in the prolongevity regimens.