Christian U. Stirnimann

TL;DR: The WD40 domain distributions in protein networks and structures of WD40-containing assemblies are discussed to demonstrate their versatility in mediating critical cellular functions.

TL;DR: In this paper, the T-box TF TBX5 and the homeodomain TF NKX2-5 co-crystal structures bound to DNA were found to have a direct interaction between the two factors and induced DNA bending.

TL;DR: D from Escherichia coli catalyzes the transport of electrons from cytoplasmic thioredoxin to the periplasmic disulfide isomerase DsbC, and the crystal structure of this catalytic intermediate was solved at 2.85 Å resolution, which revealed large relative domain movements in DsbD as a consequence of a strong overlap between the surface areas of nDsbD that interact with DSBC and cdsbD.

TL;DR: Functional and structural investigations of the Ost3/6p components of the yeast enzyme show that eukaryotic oligosaccharyltransferase is a multifunctional enzyme that acts at the crossroads of protein modification and protein folding.

TL;DR: The crystal structure of the disulfide-linked complex between nDsbD and the soluble part of CcmG is determined and the N-terminal segment of ndsbD contributes to specific recognition of C cmG constitute the structural basis for the adaptability of nDs bD to different protein substrates.