Christina Leutwein

TL;DR: The analysis provides an outline of the eukaryotic proteome as a network of protein complexes at a level of organization beyond binary interactions, which contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery.

TL;DR: Interactions of known three-dimensional structure are used to model a large set of yeast complexes and suggest atomic details not easily seen by homology, involving the combination of two or more known structures.

TL;DR: A model of the yeast exosome based on the bacterial degradosome component polynucleotide phosphorylase (PNPase) is presented and suggests numerous experiments to probe exosomes function, particularly with respect to subunits making direct atomic contacts and conserved, possibly functional residues within the predicted central pore of the complex.

TL;DR: In this article, the authors proposed a method to obtain multiprotein complexes from eukaryotes by using a protein as a bait and isolating the set of proteins which are attached thereto from cells.