Miro Brajenovic

TL;DR: The analysis provides an outline of the eukaryotic proteome as a network of protein complexes at a level of organization beyond binary interactions, which contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery.

TL;DR: These findings suggest co-regulation and/or signaling events between the distinct Par complexes and provide a basis for further elucidation of the molecular mechanisms that govern cell polarity.

TL;DR: It is suggested that although the four MARK/PAR-1 kinases might play multiple cellular roles in concert with different targets, MARK4 is likely to be directly involved in microtubule organization in neuronal cells and may contribute to the pathological phosphorylation of tau in Alzheimer's disease.

TL;DR: This study describes, for the first time, the application of the tandem affinity purification (TAP) and LC-MS method to the characterization of protein complexes from transgenic mice, allowing the identification of almost 40 novel 14-3-3ζ-binding proteins.

TL;DR: In this paper, the authors present a novel component of the cleavage/polyadenylation machinery of precursor mRNA as well as the complex containing the new components and its use.