Bettina Huhse

TL;DR: The analysis provides an outline of the eukaryotic proteome as a network of protein complexes at a level of organization beyond binary interactions, which contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery.

TL;DR: The mapping of a protein interaction network around 32 known and candidate TNF-α/NF-κB pathway components is reported by using an integrated approach comprising tandem affinity purification, liquid-chromatography tandem mass spectrometry, network analysis and directed functional perturbation studies using RNA interference.

TL;DR: In this article, a method for using protein complexes of the Tumor necrosis factor-α-signaling pathway, component proteins of said complexes, fragments and derivatives of the component proteins and antibodies specific to the complexes is presented.

TL;DR: The authors concerne les complexes proteiques de la voie de signalisation du facteur de necrose tumorale alpha (TNF-α), les proteines composant ces complexes, les fragments and derives of ces proteines, ainsi que les anticorps specifiques aux complexes.