C
Christina M. Agapakis
Researcher at University of California, Los Angeles
Publications - 24
Citations - 1187
Christina M. Agapakis is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Synthetic biology & Single-nucleotide polymorphism. The author has an hindex of 14, co-authored 24 publications receiving 1048 citations. Previous affiliations of Christina M. Agapakis include Broad Institute & Harvard University.
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Journal ArticleDOI
Natural strategies for the spatial optimization of metabolism in synthetic biology.
TL;DR: This review highlights natural and synthetic examples of three-dimensional metabolism both inter- and intracellularly, offering tools and perspectives for biological design.
Journal ArticleDOI
Plant-associated symbiotic Burkholderia species lack hallmark strategies required in mammalian pathogenesis
Annette A. Angus,Christina M. Agapakis,Stephanie Fong,Shailaja Yerrapragada,Paulina Estrada-de los Santos,Paul Yang,Nannie Song,Stephanie Kano,Jesús Caballero-Mellado,Sergio Miana de Faria,Felix D. Dakora,George M. Weinstock,Ann M. Hirsch +12 more
TL;DR: The pathogenic potential of several of the symbiotic Burkholderia strains is addressed using bioinformatics and functional tests, showing that the risk of opportunistic infection by symbiotic strains such as B. tuberum is extremely low.
Journal ArticleDOI
Insulation of a synthetic hydrogen metabolism circuit in bacteria.
Christina M. Agapakis,Daniel C. Ducat,Daniel C. Ducat,Patrick M. Boyle,Edwin H Wintermute,Jeffrey C. Way,Pamela A. Silver,Pamela A. Silver +7 more
TL;DR: It is shown that a synthetic hydrogen-producing electron transfer circuit in Escherichia coli can be insulated from existing cellular metabolism via multiple approaches, in many cases improving the function of the pathway.
Journal ArticleDOI
A survey of the microbial community in the rhizosphere of two dominant shrubs of the Negev Desert highlands, Zygophyllum dumosum (Zygophyllaceae) and Atriplex halimus (Amaranthaceae), using cultivation-dependent and cultivation-independent methods
Drora Kaplan,Maskit Maymon,Christina M. Agapakis,Andrew Lee,Andrew Wang,Barry A. Prigge,Mykola Volkogon,Ann M. Hirsch +7 more
TL;DR: A snapshot of the microbial communities in the Negev Desert, giving an insight in its natural state, identified a number of PGPB, both epiphytes and endophytes, which fix nitrogen, chelate iron, solubilize phosphate, and secrete cellulase, thereby providing a profile of the microbiomes that support the growth of two desert perennials.
Journal ArticleDOI
Towards a Synthetic Chloroplast
Christina M. Agapakis,Henrike Niederholtmeyer,Ramil R. Noche,Tami D. Lieberman,Sean G. Megason,Jeffrey C. Way,Pamela A. Silver,Pamela A. Silver +7 more
TL;DR: The results show that it is possible to engineer photosynthetic bacteria to invade the cytoplasm of mammalian cells for further engineering and applications in synthetic biology.