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Christina M. Kochel
Researcher at Johns Hopkins University
Publications - 15
Citations - 1379
Christina M. Kochel is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Immunotherapy & Cancer. The author has an hindex of 10, co-authored 13 publications receiving 993 citations. Previous affiliations of Christina M. Kochel include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen.
Andrew B. Sharabi,Christopher J. Nirschl,Christina M. Kochel,Thomas R. Nirschl,Brian Francica,Esteban Velarde,Theodore L. DeWeese,Charles G. Drake +7 more
TL;DR: The ability of stereotactic XRT to induce endogenous antigen-specific immune responses when it is combined with anti–PD-1 checkpoint blockade immunotherapy is demonstrated and provides an additional mechanistic rationale for combining radiation with PD-1 blockade in the clinic.
Journal ArticleDOI
Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy
Ariel E. Marciscano,Ali Ghasemzadeh,Thomas R. Nirschl,Debebe Theodros,Christina M. Kochel,Brian Francica,Yuki Muroyama,Robert A. Anders,Andrew B. Sharabi,Esteban Velarde,Wendy Mao,Kunal R. Chaudhary,Matthew G. Chaimowitz,John Wong,Mark J. Selby,Kent B. Thudium,Alan J. Korman,David Ulmert,Daniel L.J. Thorek,Theodore L. DeWeese,Charles G. Drake +20 more
TL;DR: It is highlighted that irradiation of the DLN restrains adaptive immune responses through altered chemokine expression and CD8+ T-cell trafficking and has implications for combining radiotherapy and ICB, long-term survival, and induction of immunologic memory.
Journal ArticleDOI
Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance.
Allison Martin,Thomas R. Nirschl,Christopher J. Nirschl,Brian Francica,Christina M. Kochel,A van Bokhoven,Alan K. Meeker,M S Lucia,Robert A. Anders,Angelo M. DeMarzo,Charles G. Drake +10 more
TL;DR: In human prostate cancer, PTEN loss is not associated with PD-L1 expression, arguing against innate immune resistance as a mechanism that mitigates antitumor immune responses in this disease.
Journal ArticleDOI
Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment
Yuki Muroyama,Thomas R. Nirschl,Christina M. Kochel,Zoila A. Lopez-Bujanda,Debebe Theodros,Wendy Mao,Maria A. Carrera-Haro,Ali Ghasemzadeh,Ariel E. Marciscano,Esteban Velarde,Ada J. Tam,Christopher J. Thoburn,Muniza Uddin,Alan K. Meeker,Robert A. Anders,Drew M. Pardoll,Charles G. Drake +16 more
TL;DR: The results suggest that RT might be combined effectively with Treg-targeting agents to maximize antitumor efficacy and demonstrate that RT increased phenotypically and functionally suppressive Tregs in the TME.
Journal ArticleDOI
Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
Nicholas M. Durham,Christopher J. Nirschl,Christopher M. Jackson,Jimmy Elias,Christina M. Kochel,Robert A. Anders,Charles G. Drake +6 more
TL;DR: The data suggest that LAG-3 expression on Tconv cells makes them more susceptible to Treg based suppression, and also regulates the development of a TH1 T-cell response, which is critical for homeostatic proliferation in vivo.