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Esteban Velarde
Researcher at Johns Hopkins University School of Medicine
Publications - 26
Citations - 1493
Esteban Velarde is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Immunotherapy & Radiation therapy. The author has an hindex of 11, co-authored 24 publications receiving 1110 citations. Previous affiliations of Esteban Velarde include Johns Hopkins University.
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Journal ArticleDOI
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen.
Andrew B. Sharabi,Christopher J. Nirschl,Christina M. Kochel,Thomas R. Nirschl,Brian Francica,Esteban Velarde,Theodore L. DeWeese,Charles G. Drake +7 more
TL;DR: The ability of stereotactic XRT to induce endogenous antigen-specific immune responses when it is combined with anti–PD-1 checkpoint blockade immunotherapy is demonstrated and provides an additional mechanistic rationale for combining radiation with PD-1 blockade in the clinic.
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Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas
Jennifer E. Kim,Mira A. Patel,Antonella Mangraviti,Eileen S. Kim,Debebe Theodros,Esteban Velarde,Ann Liu,Eric W. Sankey,Ada Tam,Haiying Xu,Dimitrios Mathios,Christopher M. Jackson,Sarah Harris-Bookman,Tomas Garzon-Muvdi,Mary Sheu,Allison Martin,Betty Tyler,Phuoc T. Tran,Xiaobu Ye,Alessandro Olivi,Janis M. Taube,Peter C. Burger,Charles G. Drake,Henry Brem,Drew M. Pardoll,Michael Lim +25 more
TL;DR: This is the first preclinical investigation on the effects of dual PD-1 and TIM-3 blockade with radiation and provides preclinical evidence for a novel treatment combination that can potentially result in long-term glioma survival and constitutes a novel immunotherapeutic strategy for the treatment of glioblastoma multiforme.
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Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy
Ariel E. Marciscano,Ali Ghasemzadeh,Thomas R. Nirschl,Debebe Theodros,Christina M. Kochel,Brian Francica,Yuki Muroyama,Robert A. Anders,Andrew B. Sharabi,Esteban Velarde,Wendy Mao,Kunal R. Chaudhary,Matthew G. Chaimowitz,John Wong,Mark J. Selby,Kent B. Thudium,Alan J. Korman,David Ulmert,Daniel L.J. Thorek,Theodore L. DeWeese,Charles G. Drake +20 more
TL;DR: It is highlighted that irradiation of the DLN restrains adaptive immune responses through altered chemokine expression and CD8+ T-cell trafficking and has implications for combining radiotherapy and ICB, long-term survival, and induction of immunologic memory.
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Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment
Yuki Muroyama,Thomas R. Nirschl,Christina M. Kochel,Zoila A. Lopez-Bujanda,Debebe Theodros,Wendy Mao,Maria A. Carrera-Haro,Ali Ghasemzadeh,Ariel E. Marciscano,Esteban Velarde,Ada J. Tam,Christopher J. Thoburn,Muniza Uddin,Alan K. Meeker,Robert A. Anders,Drew M. Pardoll,Charles G. Drake +16 more
TL;DR: The results suggest that RT might be combined effectively with Treg-targeting agents to maximize antitumor efficacy and demonstrate that RT increased phenotypically and functionally suppressive Tregs in the TME.
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Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice
Daniel A. Lee,Sooyeon Yoo,Thomas Pak,Juan Salvatierra,Esteban Velarde,Susan Aja,Seth Blackshaw +6 more
TL;DR: It is reported that high fat diet (HFD) selectively activates neurogenesis in the median eminence (ME) of young adult female but not male mice, and that focal irradiation of the ME in HFD-fed mice reduces weight gain in females but not males.