C
Christina Roark
Researcher at National Jewish Health
Publications - 8
Citations - 609
Christina Roark is an academic researcher from National Jewish Health. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 5, co-authored 8 publications receiving 589 citations.
Papers
More filters
Journal ArticleDOI
IL-17A Produced by γδ T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver
Satoru Hamada,Masayuki Umemura,Takeru Shiono,Kensho Tanaka,Ayano Yahagi,M. Dilara Begum,Kiyotetsu Oshiro,Yuko Okamoto,Hisami Watanabe,Kazuyoshi Kawakami,Christina Roark,Willi K. Born,Rebecca L. O'Brien,Koichi Ikuta,Hiromichi Ishikawa,Susumu Nakae,Yoichiro Iwakura,Takao Ohta,Goro Matsuzaki +18 more
TL;DR: The results suggest that IL-17A is a newly discovered effector molecule produced by TCR γδ T cells, which is important in innate immunity in the liver, similar to the distinction between Th17 and Th1 in CD4+ T cells.
Journal Article
Immune protection and control of inflammatory tissue necrosis by gamma delta T cells.
Yang Xin Fu,Christina Roark,Katherine A. Kelly,Douglas A. Drevets,Priscilla A. Campbell,Priscilla A. Campbell,Rebecca L. O'Brien,Rebecca L. O'Brien,Willi K. Born,Willi K. Born +9 more
TL;DR: It is concluded that gamma delta T cells are required to control inflammatory reactivity and to prevent excessive liver damage during the immune response to Listeria monocytogenes.
Journal Article
Response of a gamma delta+ T cell receptor invariant subset during bacterial infection.
TL;DR: The results indicate that only diverse, but also invariant, gamma delta T cell subsets can become involved in the host response to a bacterial infection, and that the Ag that stimulates these cells is unknown.
Journal Article
Liver gamma delta T cells. TCR junctions reveal differences in heat shock protein-60-reactive cells in liver and spleen.
Christina Roark,Michaelann Vollmer,Robin Cranfill,Simon R. Carding,W Born,Rebecca L. O'Brien +5 more
TL;DR: The data suggest that HSP-60-reactive gamma delta cells in adult murine liver and spleen are independent of each other and may be resident in their respective sites.
Patent
Use of soluble gamma delta t cell receptors for regulating t cell function
TL;DR: In this article, a method of using soluble Ϝδ T cell receptors to regulate a πδT cell-mediated immune response in a mammal is described, which is called disclosed.