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Rebecca L. O'Brien
Researcher at University College Cork
Publications - 143
Citations - 9236
Rebecca L. O'Brien is an academic researcher from University College Cork. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 48, co-authored 142 publications receiving 8653 citations. Previous affiliations of Rebecca L. O'Brien include Anschutz Medical Campus & University of Colorado Denver.
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Journal ArticleDOI
Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity.
TL;DR: Recent observations reveal the ability of γδ T cells to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress, and insights are provided into how they acquire these properties.
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Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from mycobacterium tuberculosis
TL;DR: Surprisingly, every spontaneously reactive γδ + hybridoma was further stimulated by purified protein derivative of Mycobacterium tuberculosis, perhaps due to crossreaction with a bacterial antigen homologous to certain eukaryotic heat shock proteins.
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Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung
Yuko Okamoto Yoshida,Masayuki Umemura,Ayano Yahagi,Rebecca L. O'Brien,Koichi Ikuta,Kenji Kishihara,Hiromitsu Hara,Susumu Nakae,Yoichiro Iwakura,Goro Matsuzaki +9 more
TL;DR: IL-17A produced by TCR γδ T cells plays a critical role in the prevention of M. tuberculosis infection through the induction of mature granuloma formation.
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IL-17A Produced by γδ T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver
Satoru Hamada,Masayuki Umemura,Takeru Shiono,Kensho Tanaka,Ayano Yahagi,M. Dilara Begum,Kiyotetsu Oshiro,Yuko Okamoto,Hisami Watanabe,Kazuyoshi Kawakami,Christina Roark,Willi K. Born,Rebecca L. O'Brien,Koichi Ikuta,Hiromichi Ishikawa,Susumu Nakae,Yoichiro Iwakura,Takao Ohta,Goro Matsuzaki +18 more
TL;DR: The results suggest that IL-17A is a newly discovered effector molecule produced by TCR γδ T cells, which is important in innate immunity in the liver, similar to the distinction between Th17 and Th1 in CD4+ T cells.
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γδ T cells: an important source of IL-17
TL;DR: Interestingly, some gammadelta T cells produce IL-17 in response to IL-23 alone, even in naïve animals, suggesting they are already differentiated and may develop differently than CD4(+) alphabeta Th17 cells.