C
Christina Schaub
Researcher at University Hospital Bonn
Publications - 51
Citations - 1001
Christina Schaub is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 38 publications receiving 666 citations. Previous affiliations of Christina Schaub include University of Bonn & University of Tübingen.
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Journal ArticleDOI
Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial
Ulrich Herrlinger,Theophilos Tzaridis,Frederic Mack,Joachim P. Steinbach,Uwe Schlegel,Michael Sabel,Peter Hau,Rolf-Dieter Kortmann,Dietmar Krex,Oliver Grauer,Roland Goldbrunner,Oliver Schnell,Oliver Schnell,Oliver Bähr,Martin Uhl,Clemens Seidel,Ghazaleh Tabatabai,Thomas Kowalski,Florian Ringel,Florian Ringel,Friederike Schmidt-Graf,Bogdana Suchorska,Stefanie Brehmer,Astrid Weyerbrock,Miriam Renovanz,Lars Bullinger,Norbert Galldiks,Peter Vajkoczy,Martin Misch,Hartmut Vatter,Moritz Stuplich,Niklas Schäfer,Sied Kebir,Johannes Weller,Christina Schaub,Walter Stummer,Jörg-Christian Tonn,Matthias Simon,Vera C. Keil,Michael Nelles,Horst Urbach,Horst Urbach,Martin Coenen,Wolfgang Wick,Michael Weller,Rolf Fimmers,Matthias Schmid,Elke Hattingen,Torsten Pietsch,Christoph Coch,Martin Glas,Martin Glas +51 more
TL;DR: The results suggest that lomustine-temozolomide chemotherapy might improve survival compared with temozolmide standard therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter.
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Late Pseudoprogression in Glioblastoma: Diagnostic Value of Dynamic O-(2-[18F]fluoroethyl)-L-Tyrosine PET.
Sied Kebir,Sied Kebir,Rolf Fimmers,Norbert Galldiks,Niklas Schäfer,Niklas Schäfer,Frederic Mack,Christina Schaub,Christina Schaub,Moritz Stuplich,Moritz Stuplich,Michael Niessen,Michael Niessen,Theophilos Tzaridis,Theophilos Tzaridis,Matthias Simon,Gabriele Stoffels,Karl-Josef Langen,Björn Scheffler,Martin Glas,Ulrich Herrlinger,Ulrich Herrlinger +21 more
TL;DR: PET using O-(2-[18F]fluoroethyl)-L-tyrosine PET provides valuable information in assessing the elusive phenomenon of late PsP, which may occur later in the course of the disease and may be particularly difficult to distinguish from true tumor progression.
Journal ArticleDOI
Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug
Anna Doeser,Gesa Dickhof,Margit Reitze,Mischa Uebachs,Christina Schaub,Nuno Pires,Maria João Bonifácio,Patrício Soares-da-Silva,Heinz Beck,Heinz Beck +9 more
TL;DR: It is shown that eslicarbazepine acetate exhibits maintained use-dependent blocking effects both in human and experimental epilepsy with significant add-on effects to carbamazepine in human epilepsy and also inhibits Cav3.2 T-type Ca(2+) channels, which have been shown to be key mediators of epileptogenesis.
Journal ArticleDOI
Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)
Karen M.J. van Loo,Christina Schaub,Katharina Pernhorst,Yoel Yaari,Yoel Yaari,Heinz Beck,Susanne Schoch,Albert J. Becker +7 more
TL;DR: Egr1 and REST can bi-directionally regulate CaV3.2 promoter activity and mRNA expression and, hence, the size of ICaT, which has critical implications for the regulation of neuronal and cardiac Ca2+ homeostasis under physiological conditions and in episodic disorders such as arrhythmias and epilepsy.