C
Christine E. Hajdin
Researcher at Novartis
Publications - 3
Citations - 654
Christine E. Hajdin is an academic researcher from Novartis. The author has contributed to research in topics: Druggability & Ribosomal binding site. The author has an hindex of 3, co-authored 3 publications receiving 393 citations. Previous affiliations of Christine E. Hajdin include Durham University.
Papers
More filters
Journal ArticleDOI
Principles for targeting RNA with drug-like small molecules
TL;DR: In this article, the authors discuss principles for discovering small-molecule drugs that target RNA and argue that the overarching challenge is to identify appropriate target structures - namely, in disease-causing RNAs that have high information content and, consequently, appropriate ligand-binding pockets.
Journal ArticleDOI
Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing.
Anthony M. Mustoe,Steven Busan,Greggory M. Rice,Christine E. Hajdin,Brant K. Peterson,Vera M. Ruda,Neil Kubica,Razvan Nutiu,Jeremy Baryza,Kevin M. Weeks +9 more
TL;DR: It is found that the translation efficiency of endogenous genes is regulated by unfolding kinetics of structures overlapping the ribosome binding site, and conserved structured elements are discovered in 35% of UTRs, several of which are validated as novel protein binding motifs.
Journal ArticleDOI
Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling
Mary C. Andorfer,Jonathan E. Grob,Christine E. Hajdin,Julia R. Chael,Piro Siuti,Jeremiah Lilly,Kian L. Tan,Jared C. Lewis +7 more
TL;DR: The activity of four native FDHs and four engineered FDH variants on 93 low molecular weight arenes was used to generate FDH substrate activity profiles and suggest that substrate binding can override electronic activation even on compounds differing appreciably from native substrates.