C
Christine E. Weber
Researcher at Johns Hopkins University
Publications - 8
Citations - 1149
Christine E. Weber is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Immune system & Ex vivo. The author has an hindex of 7, co-authored 8 publications receiving 1138 citations. Previous affiliations of Christine E. Weber include Johns Hopkins University School of Medicine.
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Journal Article
Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer
Jonathan W. Simons,Bahar Mikhak,Ju-Fay Chang,Angelo M. DeMarzo,Michael A. Carducci,Michael Lim,Christine E. Weber,Angelo A. Baccala Md,Marti Goemann,Shirley M. Clift,Dale G. Ando,Hyam I. Levitsky,Lawrence K. Cohen,Martin G. Sanda,Richard C. Mulligan,Alan W. Partin,H. Ballentine Carter,Steven Piantadosi,Fray F. Marshall,William G. Nelson +19 more
TL;DR: It is suggested that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines, and side effects were pruritus, erythema, and swelling at vaccination sites.
Journal Article
Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer
Jonathan W. Simons,Elizabeth M. Jaffee,Christine E. Weber,Hyam I. Levitsky,William G. Nelson,Michael A. Carducci,Audrey J. Lazenby,Lawrence K. Cohen,Christy C. Finn,Shirley M. Clift,Karen M. Hauda,Lisa A. Beck,Kristin M. Leiferman,Albert H. Owens,Steven Piantadosi,Glenn Dranoff,Richard C. Mulligan,Drew M. Pardoll,Fray F. Marshall +18 more
TL;DR: This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous GM-CSF gene-transduced tumor vaccine for RCC patients.
Journal ArticleDOI
Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
William G. Nelson,Jonathan W. Simons,Bahar Mikhak,Ju Fay Chang,Angelo M. DeMarzo,Michael A. Carducci,Michael M. Kim,Christine E. Weber,Angelo A. Baccala Md,Marti A. Goeman,Shirley M. Clift,Dale G. Ando,Hyam I. Levitsky,Lawrence K. Cohen,Martin G. Sanda,Richard C. Mulligan,Alan W. Partin,H. Ballentine Carter,Steven Piantadosi,Fray F. Marshall +19 more
TL;DR: These first clinical trials of GM-CSF-secreting cancer cell vaccines for the treatment of genitourinary cancers have demonstrated both safety and bioactivity, in that very few side effects have been seen and anticancer immune responses have been detected.
Journal ArticleDOI
A Phase I Clinical Trial of Lethally Irradiated Allogeneic Pancreatic Tumor Cells Transfected with the GM-CSF Gene for the Treatment of Pancreatic Adenocarcinoma. The Johns Hopkins Oncology Center, Baltimore, Maryland
Elizabeth M. Jaffee,Ross A. Abrams,John L. Cameron,Ross C. Donehower,Mary Duerr,Jeanette Gossett,Tim F. Greten,Louise B. Grochow,Ralph H. Hruban,Scott E. Kern,Keith D. Lillemoe,Seamus O'Reilly,Drew M. Pardoll,Henry A. Pitt,Patricia K. Sauter,Christine E. Weber,Charles J. Yeo +16 more
Journal ArticleDOI
Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer
Jonathan W. Simons,Elizabeth M. Jaffee,Christine E. Weber,Hyam I. Levitsky,William G. Nelson,Michael A. Carducci,Audrey J. Lazenby,Lawrence K. Cohen,Christy C. Finn,Shirley M. Clift,Karen M. Hauda,Lisa A. Beck,Kristin M. Leiferman,Albert H. Owens,Steven Piantadosi,Glenn Dranoff,Richard C. Mulligan,Drew M. Pardoll,Fray F. Marshall +18 more
TL;DR: A Phase I trial evaluating the safety and the induction of immune responses in patients with metastatic renal cell carcinoma (RCC) was reported in this paper. But, no evidence of autoimmune disease was observed.