Christine J. McNamee

TL;DR: Approaches used for drug repurposing (also known as drug repositioning) are presented, the challenges faced by the repurpose community are discussed, and innovative ways by which these challenges could be addressed are recommended to help realize the full potential of drugRepurposing.

TL;DR: It is confirmed that OBCam will bind homophilically and also that LAMP, OBCAM and CEPU-1 will interact heterophilic with each other and proposed that IgLON activity will depend on the complement of IgLons expressed by each neuron.

TL;DR: It is proposed that IgLONs function predominantly as subunits of heterodimeric proteins (Diglons), and although singly transfected cell lines have little effect on neurite outgrowth, CHO cell lines expressing both CEPU-1 and OBCAM (Diglon-CO) inhibit neuriteOutgrowth from cerebellar granule cells.

TL;DR: It is suggested that IgLONs may not have a primary role in axon guidance but may be more important for cell–cell adhesion and recognition.

TL;DR: The characterisation of an alternatively-spliced isoform ofCEPU-1 that is secreted is reported, suggesting that CEPU-Se may act to modulate the ability of CE PU-1, LAMP, and OBCAM to influence neurite outgrowth.