A
Andrew D. Wells
Researcher at Children's Hospital of Philadelphia
Publications - 148
Citations - 12602
Andrew D. Wells is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: T cell & Genome-wide association study. The author has an hindex of 47, co-authored 130 publications receiving 10250 citations. Previous affiliations of Andrew D. Wells include University of Wisconsin-Madison & University of New Mexico.
Papers
More filters
Journal ArticleDOI
Drug repurposing: progress, challenges and recommendations
Sudeep Pushpakom,Francesco Iorio,Patrick A. Eyers,K. Jane Escott,Shirley Hopper,Andrew D. Wells,Andrew J. Doig,Tim Guilliams,Joanna Latimer,Christine J. McNamee,Alan Norris,Philippe Sanseau,David Cavalla,Munir Pirmohamed +13 more
TL;DR: Approaches used for drug repurposing (also known as drug repositioning) are presented, the challenges faced by the repurpose community are discussed, and innovative ways by which these challenges could be addressed are recommended to help realize the full potential of drugRepurposing.
Journal ArticleDOI
Deacetylase inhibition promotes the generation and function of regulatory T cells
Ran Tao,Edwin F. de Zoeten,Engin Ozkaynak,Chunxia Chen,Liqing Wang,Paige M. Porrett,Bin Li,Laurence A. Turka,Eric N. Olson,Mark I. Greene,Andrew D. Wells,Wayne W. Hancock +11 more
TL;DR: Administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the production and suppressive function of regulatory T cells (Treg cells), and HDAC9 proved particularly important in regulatingFoxp3-dependent suppression.
Journal ArticleDOI
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
TL;DR: The data indicate that induction of T-cell apoptosis and peripheral allograft tolerance is prevented by blocking both signal 1 and signal 2 ofT-cell activation.
Journal ArticleDOI
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.
Andrew D. Wells,Xian Chang Li,Yongsheng Li,Matthew C. Walsh,Xin Xiao Zheng,Zihao Wu,Gabriel Núñez,Aimin Tang,Mohamed H. Sayegh,Wayne W. Hancock,Terry B. Strom,Laurence A. Turka +11 more
TL;DR: It is found that mice with defective passive or active T-cell apoptotic pathways were resistant to induction of transplantation tolerance, and deletion of activated T cells through activation-induced cell death or growth factor withdrawal seems necessary to achieve peripheral tolerance across major histocompatibility complex barriers.
Journal ArticleDOI
Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question.
Elliot J. Suchin,Peter B. Langmuir,Ed Palmer,Mohamed H. Sayegh,Andrew D. Wells,Laurence A. Turka +5 more
TL;DR: It is concluded that accurate calculations of alloreactive precursor frequency must account for both proliferation and cell engraftment, and that bystander proliferation is negligible, revealing exquisite specificity to the alloresponse.