A
Alan Norris
Researcher at University of Liverpool
Publications - 6
Citations - 2524
Alan Norris is an academic researcher from University of Liverpool. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 5, co-authored 6 publications receiving 1365 citations.
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Journal ArticleDOI
Drug repurposing: progress, challenges and recommendations
Sudeep Pushpakom,Francesco Iorio,Patrick A. Eyers,K. Jane Escott,Shirley Hopper,Andrew D. Wells,Andrew J. Doig,Tim Guilliams,Joanna Latimer,Christine J. McNamee,Alan Norris,Philippe Sanseau,David Cavalla,Munir Pirmohamed +13 more
TL;DR: Approaches used for drug repurposing (also known as drug repositioning) are presented, the challenges faced by the repurpose community are discussed, and innovative ways by which these challenges could be addressed are recommended to help realize the full potential of drugRepurposing.
Journal ArticleDOI
Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury
Michael J. Cross,Brian R. Berridge,P J M Clements,Laura Cove-Smith,Thomas Force,P Hoffmann,M Holbrook,Alexander R. Lyon,Howard R. Mellor,Alan Norris,Munir Pirmohamed,Jonathan Tugwood,James E. Sidaway,B.K. Park +13 more
TL;DR: A workshop organized by the Medical Research Council Centre for Drug Safety Science and attended by industry, academia and regulatory representatives, was designed to gain a better understanding of the gaps in the field of structural cardiotoxicity.
Journal ArticleDOI
Stem cell–derived models to improve mechanistic understanding and prediction of human drug-induced liver injury
Christopher E. Goldring,Daniel J. Antoine,Frank Bonner,Jonathan Crozier,Chris Denning,Robert J. Fontana,Neil A. Hanley,David C. Hay,Magnus Ingelman-Sundberg,Satu Juhila,Neil R. Kitteringham,Beatriz Silva-Lima,Alan Norris,Chris S. Pridgeon,James A. Ross,Rowena Sison Young,Danilo Tagle,Belen Tornesi,Bob van de Water,Richard J. Weaver,Fang Zhang,B. Kevin Park +21 more
TL;DR: The importance of benchmarking stem cell–derived hepatocyte‐like cells to their terminally differentiated human counterparts using defined phenotyping is discussed, to make sure the cells are relevant and comparable between labs, and outline why this process is essential before the cells is introduced into chemical safety assessment.
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Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury
Daniel F. Carr,Seyoum Ayehunie,Andrea Davies,Carrie A. Duckworth,Stephanie French,Neil Hall,Syed A. Hussain,Howard R. Mellor,Alan Norris,B. Kevin Park,Alexander Penrose,D. Mark Pritchard,Chris Probert,Shashi K. Ramaiah,Claire Sadler,Michael Schmitt,Alison Shaw,James E. Sidaway,Robert G. Vries,Matthew Wagoner,Munir Pirmohamed +20 more
TL;DR: This review will cover the current knowledge of GI ADRs, existing biomarkers and models with potential application for toxicity screening/monitoring, and recommend that a systematic approach is needed to identify mechanism‐based GI biomarkers with potential for clinical translation.
Journal ArticleDOI
New Approaches to Investigate Drug-Induced Hypersensitivity
Monday O. Ogese,Monday O. Ogese,S Ahmed,Ana Alferivic,Catherine J. Betts,Anne M. Dickinson,Lee Faulkner,Neil French,Andrew Gibson,Gideon M. Hirschfield,Michael Kammüller,Xiaoli Meng,Stefan F. Martin,P. Musette,Alan Norris,Munir Pirmohamed,B. Kevin Park,Anthony W. Purcell,Colin F. Spraggs,Jessica Whritenour,Dean J. Naisbitt +20 more
TL;DR: This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.