C
Christine Jaxel
Researcher at University of Paris-Sud
Publications - 38
Citations - 2137
Christine Jaxel is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Topoisomerase & DNA supercoil. The author has an hindex of 22, co-authored 35 publications receiving 2073 citations. Previous affiliations of Christine Jaxel include Centre national de la recherche scientifique & Commissariat à l'énergie atomique et aux énergies alternatives.
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Journal Article
Structure-Activity Study of the Actions of Camptothecin Derivatives on Mammalian Topoisomerase I: Evidence for a Specific Receptor Site and a Relation to Antitumor Activity
TL;DR: Stereochemistry and the positions of substituents were found to be crucial for the presence or absence of effects on topoisomerase I, indicating that the compounds interact with an asymmetrical receptor site on the enzyme or enzyme-DNA complex.
Journal Article
Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.
TL;DR: The hypothesis that DNA single-strand breaks and DNA-protein cross-links induced by camptothecin in mammalian cells are due to an action on topoisomerase I is supported.
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Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
TL;DR: Results indicate that camptothecin traps preferentially a subset of the enzyme cleavage sites, those having a G immediately 3' to the cleaved bond, in analogy to a model previously proposed for inhibitors of topoisomerase II.
Journal Article
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.
TL;DR: The data indicate that some DNA intercalators are not only inhibitors of DNA topoisomerase II but act also on DNA top Loisomerase I, and the stabilization of cleavage intermediates by intercalator may have a common mechanism for DNA topISomersase I and DNA topisomersase II.
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Crystallization of a mammalian membrane protein overexpressed in Saccharomyces cerevisiae.
Marie Jidenko,Rikke Nielsen,Thomas Sorensen,Jesper V. Møller,Marc le Maire,Poul Nissen,Christine Jaxel +6 more
TL;DR: This represents a successful crystallization of a mammalian membrane protein derived from a heterologous expression system, and it opens the way for the study of mutant forms of SERCA1a.