Christine L. Remmers

TL;DR: It is demonstrated that imatinib, an anticancer drug previously found to inhibit amyloid-β formation without affecting Notch cleavage, achieves its amyloids-β-lowering effect by preventing GSAP interaction with the γ-secretase substrate, APP-CTF.

TL;DR: In this paper, a photochemical cross-linking technique was employed to examine intermolecular interactions of full-length Tau in vitro and showed that dimerization is an early event in the Tau aggregation process and that these dimers self-associate to form larger oligomeric aggregates.

TL;DR: Examination of synaptic transmission during long sustained trains of activity suggested that the readily releasable pool of vesicles is reduced in Epac2−/− mice, and data suggest that cAMP elevation uses an Epac 2-dependent pathway to promote transmitter release, and thatEpac2 is required to maintain the readily RELEASable pool at MF synapses in the hippocampus.

TL;DR: Evidence is provided that the function of fast-spiking interneurons is disrupted due to a deficiency in neurotrophin signaling during early development in FXS, and the maturation of the GABAergic circuit in the sensory cortex is altered during a critical developmental period.

TL;DR: The results suggest repeated PCP administration causes a long-lasting metaplastic change in the inhibitory circuits in the hippocampus that results in impaired LTP, and could contribute to the deficits in hippocampal-dependent memory in PCP-treated mice.