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Yifan Fu
Researcher at Northwestern University
Publications - 18
Citations - 2535
Yifan Fu is an academic researcher from Northwestern University. The author has contributed to research in topics: Tau protein & Epitope. The author has an hindex of 14, co-authored 14 publications receiving 2349 citations. Previous affiliations of Yifan Fu include University of California, Los Angeles.
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Journal ArticleDOI
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
T. Chris Gamblin,Feng Chen,Angara Zambrano,Aida Abraha,Sarita Lagalwar,Angela L. Guillozet,Meiling Lu,Yifan Fu,Francisco García-Sierra,Nichole E. LaPointe,Richard J. Miller,Robert W. Berry,Lester I. Binder,Vincent L. Cryns +13 more
TL;DR: A novel mechanism linking amyloid deposition and neurofibrillary tangles in AD is suggested: Aβ peptides promote pathological tau filament assembly in neurons by triggering caspase cleavage of tau and generating a proteolytic product with enhanced polymerization kinetics.
Journal ArticleDOI
β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis
Jie Zhao,Yifan Fu,Marina V. Yasvoina,Peizhen Shao,Brian Hitt,Tracy O'Connor,Sreemathi Logan,Erika Maus,Martin Citron,Robert W. Berry,Lester I. Binder,Robert Vassar +11 more
TL;DR: It is concluded that BACE1 elevation is most likely triggered by the amyloid pathway and may drive a positive-feedback loop in AD.
Journal ArticleDOI
Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease
Angela L. Guillozet-Bongaarts,Francisco García-Sierra,Matthew R. Reynolds,Peleg M. Horowitz,Yifan Fu,Tianyi Wang,Michael E. Cahill,Eileen H. Bigio,Robert W. Berry,Lester I. Binder +9 more
TL;DR: Creation of the Tau-C3 epitope appears to occur relatively early in the disease state, contemporaneous with the initial Alz50 folding event that heralds the appearance of filamentous tau in NFTs, neuropil threads, and the dystrophic neurites surrounding amyloid plaques.
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Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases
Nicholas M. Kanaan,Gerardo Morfini,Gerardo Morfini,Nichole E. LaPointe,Gustavo Pigino,Gustavo Pigino,Kristina R. Patterson,Yuyu Song,Athena Andreadis,Yifan Fu,Scott T. Brady,Scott T. Brady,Lester I. Binder +12 more
TL;DR: A novel role for tau in modulating axonal phosphotransferases is revealed and the molecular basis for a toxic gain-of-function associated with pathogenic forms of tau is provided.
Journal ArticleDOI
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.
Kristina R. Patterson,Christine L. Remmers,Yifan Fu,Sarah M. Brooker,Nicholas M. Kanaan,Laurel Vana,Sarah Ward,Juan F. Reyes,Keith D. Philibert,Marc J. Glucksman,Lester I. Binder +10 more
TL;DR: In this paper, a photochemical cross-linking technique was employed to examine intermolecular interactions of full-length Tau in vitro and showed that dimerization is an early event in the Tau aggregation process and that these dimers self-associate to form larger oligomeric aggregates.