Christine Xu

TL;DR: Evaluation of the safety, tolerability, and pharmacokinetics of viramidine in healthy male volunteers after oral dosing ofviramidine at 200, 600, and 1200 mg found that the main route of elimination for both vir amidine and ribavirin is metabolism.

TL;DR: The pharmacokinetics, pharmacodynamics and tolerability of ascending single doses of fedratinib were assessed in healthy male subjects, and suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation, indicative of JAK2 inhibition, was observed at 3 hours post‐dose.

TL;DR: An accurate and highly specific LC-MS/MS method for the simultaneous analyses of viramidine and ribavirin in human plasma was developed and validated, and provides a useful method for evaluating the pharmacokinetics of vir amidine and Ribaviral in man following administration ofviramidine.

TL;DR: Food intake had minimal impact on the pharmacokinetics of fedratinib, and the tolerability of this drug was improved when taken following a high‐fat breakfast.

TL;DR: Higher RO was associated with greater CRP reduction and 28‐joint Disease Activity Score based onCRP reduction, and more sarilumab patients achieving 20%/50%/70% improvement in American College of Rheumatology responses.