Christoph S. Clemen

TL;DR: This review summarizes the currently available data on the epidemiology, clinical phenotypes, myopathology, and genetics of desminopathies, and provides an overview on the expression, filament formation processes, biomechanical properties, post-translational modifications, interaction partners, subcellular localization, and functions of wild-type and mutant desmin as well as desmin-related cell and animal models.

TL;DR: The search for putative ligands to the R93 and R155 cavities resulted in the identification of cyclic sugar compounds with high binding scores, which provide a novel link to VCP carbohydrate interactions in the complex pathology of IBMPFD.

TL;DR: It is demonstrated that the combinatorial effect of suboptimal SMN antisense oligonucleotide treatment and PLS3 overexpression-a situation resembling the human condition in asymptomatic SMN1-deleted individuals-rescues survival and motoric abilities in a severe SMA mouse model.

TL;DR: Recent data is reviewed providing more insight into molecular mechanisms underlying the regulation of F‐actin structures, cytoskeletal rearrangements and intracellular membrane transport by coronin proteins and the way that they might link cytoskeleton with trafficking in development and disease.

TL;DR: Ins infection of erythrocytes from human sickle cell trait carriers with ring stages of P. falciparum led to significantly enhanced PGE2 formation, Ca2+ permeability, annexin-A7 degradation, phosphatidylserine exposure at the cell surface, and clearance by macrophages.