Stefan Laufer

TL;DR: There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2, and chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral Drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may prevent spread.

TL;DR: An overview of warheads-beyond α,β-unsaturated amides-recently used in the design of targeted covalent ligands is provided, with special emphasis on the discussion of reactivity and of case studies illustrating applications in medicinal chemistry and chemical biology.

TL;DR: Skepinone-L did not impair platelet Ca2+ signaling but prevented agonist-induced thromboxane A2 synthesis through abrogation of p38 MAPK-dependent phosphorylation of platelet cytosolic phospholipase A2 (cPLA2).

TL;DR: The scratch assay in the present form can be used as a promising scientific approach and platform to differentiate between plant extracts known for their wound healing and their anti-inflammatory properties.

TL;DR: A system that enables pooled shRNA screening directly in mouse hepatocellular carcinomas in vivo to identify genes likely to be involved in therapy resistance is described, suggesting that a combination of sorafenib and Mapk14 blockade is a promising approach to overcoming therapy resistance of human HCC.