C
Christoph Wotzlaw
Researcher at University of Duisburg-Essen
Publications - 25
Citations - 1632
Christoph Wotzlaw is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Förster resonance energy transfer & Gene expression. The author has an hindex of 16, co-authored 25 publications receiving 1543 citations. Previous affiliations of Christoph Wotzlaw include Max Planck Society.
Papers
More filters
Journal ArticleDOI
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.
Eric Metzen,Utta Berchner-Pfannschmidt,Petra Stengel,Jan H. Marxsen,Ineke Stolze,Matthias Klinger,Wei Qi Huang,Christoph Wotzlaw,Thomas Hellwig-Bürgel,Wolfgang Jelkmann,Helmut Acker,Joachim Fandrey +11 more
TL;DR: It is proposed that PHDs and FIH-1 form an oxygen sensor cascade of distinct subcellular localisation, which results in the decreased ability of HIF-1 to bind to the transcriptional coactivator p300/CBP.
Journal ArticleDOI
Two-photon fluorescence absorption and emission spectra of dyes relevant for cell imaging
Felix Bestvater,Eberhard Spiess,G. Stobrawa,Martin Hacker,Thomas Feurer,Torsten Porwol,Utta Berchner-Pfannschmidt,Christoph Wotzlaw,Helmut Acker +8 more
TL;DR: The potential of non‐linear laser scanning fluorescence microscopy is demonstrated here by visualizing multiple intracellular structures in living cells and combined with 3D reconstruction techniques, this approach gives a deeper insight into the spatial relationships of subcellular organelles.
Journal ArticleDOI
A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression
Qing Liu,Utta Berchner-Pfannschmidt,Ulrike Möller,Martina Brecht,Christoph Wotzlaw,Helmut Acker,Kurt Jungermann,Thomas Kietzmann +7 more
TL;DR: The localized Fenton reaction appears to impact the expression of hypoxia-regulated genes by means of HIF-1α stabilization and coactivator recruitment.
Original Contribution The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells
Talija Djordjevic,Alexej Pogrebniak,Rachida S. BelAiba,Steve Bonello,Christoph Wotzlaw,Helmut Acker,John Hess,Agnes Gfrlach +7 more
TL;DR: Findings suggest a positive feedback mechanism whereby ROS, possibly generated by the NADPH oxidase, lead to elevated levels of p22phox and, thus, sustained ROS generation as is observed in endothelial dysfunction.
Journal ArticleDOI
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells.
Talija Djordjevic,Alexej Pogrebniak,Rachida S. BelAiba,Steve Bonello,Christoph Wotzlaw,Helmut Acker,John Hess,Agnes Görlach +7 more
TL;DR: In this paper, the role of thrombin in regulating NADPH oxidase-dependent ROS production and expression of its subunit p22phox in the endothelial cell line EaHy926 was investigated.