Christophe Cazaux

TL;DR: Cloned hamster Rad51 cDNA and overexpression of the protein stimulated the homologous recombination between integrated genes by 20-fold indicating that Rad51 is a functional and key enzyme of an intrachromosomal recombination pathway.

TL;DR: It is shown that cells overexpressing pol beta cDNA have acquired a spontaneous mutator phenotype, and data is presented in support of error-prone translesion replication as one of the key determinants of tolerance phenotype.

TL;DR: Among the 13 human nuclear DNA polymerase genes, DNA Polymerase θ (POLQ) is the only one significantly up-regulated in breast cancer compared with normal breast tissues, and POLQ expression provides thus an additional indicator for the survival outcome of patients with high Cyclin E tumor expression or high number of positive lymph nodes.

TL;DR: Pol η–dependent DNA synthesis at stalled replication forks during S phase suppresses chronic fragile site instability by preventing checkpoint-blind under-replicated DNA in mitosis.

TL;DR: E ectopic expression in cells of DNA polymerase β, an error-prone enzyme frequently over-regulated in human tumors, induces aneuploidy, an abnormal localization of the centrosome-associated γ-tubulin protein during mitosis, a deficient mitotic checkpoint, and promotes tumorigenesis in nude immunodeficient mice.