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Christopher Burlak
Researcher at University of Minnesota
Publications - 100
Citations - 2820
Christopher Burlak is an academic researcher from University of Minnesota. The author has contributed to research in topics: Xenotransplantation & Transplantation. The author has an hindex of 28, co-authored 99 publications receiving 2429 citations. Previous affiliations of Christopher Burlak include Indiana University & Miami University.
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Journal Article
Neutrophils in the innate immune response.
TL;DR: The role of human neutrophils in the innate host response to infection is provided and some of the recent advances in neutrophil biology are summarized.
Journal ArticleDOI
Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation.
Andrew J. Lutz,Ping Li,Jose L. Estrada,R A Sidner,Ray K. Chihara,Susan M. Downey,Christopher Burlak,Zheng-Yu Wang,Luz M. Reyes,Bess Ivary,Fuqin Yin,Ross L. Blankenship,Leela L. Paris,A. Joseph Tector +13 more
TL;DR: Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells, and only two known xenoantigens are known.
Journal ArticleDOI
Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
Wei Wang,Linh T.T. Nguyen,Christopher Burlak,Fariba Chegini,Feng Guo,Tim Chataway,Shulin Ju,Oriana S. Fisher,David Miller,Debajyoti Datta,Fang Wu,Chun Xiang Wu,Anuradha Landeru,James A. Wells,Mark R. Cookson,Matthew B. Boxer,Craig J. Thomas,Wei Ping Gai,Dagmar Ringe,Gregory A. Petsko,Gregory A. Petsko,Gregory A. Petsko,Quyen Q. Hoang +22 more
TL;DR: In this paper, the role of inflammation in the aggregation of α-synuclein (aSyn) is investigated in a neuronal cell model of Parkinson's disease (PD) and it is shown that activation of the inflammasome with known stimuli results in aggregation of aSyn.
Journal ArticleDOI
Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection.
Christopher Burlak,Carl H. Hammer,Mary Ann Robinson,Adeline R. Whitney,Martin J. McGavin,Barry N. Kreiswirth,Frank R. DeLeo +6 more
TL;DR: It is concluded that the exoproteins identified herein likely account in part for the success of CA‐MRSA as a human pathogen.
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein
Wei Wang,Linh T.T. Nguyen,Christopher Burlak,Fariba Chegini,Feng Guo,Tim Chataway,Shulin Ju,Oriana S. Fisher,David Miller,Debajyoti Datta,Fang Wu,Chun Xiang Wu,Anuradha Landeru,James A. Wells,Mark R. Cookson,Matthew B. Boxer,Craig J. Thomas,Wei Ping Gai,Dagmar Ringe,Gregory A. Petsko,Gregory A. Petsko,Gregory A. Petsko,Quyen Q. Hoang +22 more
TL;DR: It is reported that inflammation can play a role in causing the aggregation of wild type aSyn, and perhaps in the pathogenesis of sporadic PD as well.