C
Christopher Carroll
Researcher at University of Sheffield
Publications - 144
Citations - 9335
Christopher Carroll is an academic researcher from University of Sheffield. The author has contributed to research in topics: Systematic review & Cost effectiveness. The author has an hindex of 49, co-authored 131 publications receiving 7666 citations. Previous affiliations of Christopher Carroll include University College London & University of Helsinki.
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A conceptual framework for implementation fidelity
TL;DR: A critical review of existing conceptualisations of implementation fidelity and a new conceptual framework for understanding and measuring the process are developed, which requires testing by empirical research.
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Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
Nahid Akhtar Khan,Mari Auranen,Mari Auranen,Ilse Paetau,Eija Pirinen,Eija Pirinen,Liliya Euro,Saara Forsström,Lotta Pasila,Vidya Velagapudi,Christopher Carroll,Johan Auwerx,Anu Suomalainen,Anu Suomalainen +13 more
TL;DR: NR effectively delayed early‐ and late‐stage disease progression, by robustly inducing mitochondrial biogenesis in skeletal muscle and brown adipose tissue, preventing mitochondrial ultrastructure abnormalities and mtDNA deletion formation, suggesting its protective role in mitochondrial disease.
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“Best fit” framework synthesis: refining the method
TL;DR: The method is suited to producing context-specific conceptual models for describing or explaining the decision-making and health behaviours of patients and other groups and offers a pragmatic means of conducting rapid qualitative evidence synthesis and generating programme theories relating to intervention effectiveness.
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A worked example of "best fit" framework synthesis: A systematic review of views concerning the taking of some potential chemopreventive agents
TL;DR: The novel and pragmatic approach to framework synthesis developed and described here was found to be fit for purpose and future research should seek to test further this approach to qualitative data synthesis.
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Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
Lauren M. Valentim,Kevin M. Laurence,Paul A. Townsend,Christopher Carroll,Surinder M. Soond,Tiziano M. Scarabelli,Richard A. Knight,David S. Latchman,Anastasis Stephanou +8 more
TL;DR: It is demonstrated that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adult rat cardiac myocytes) and reduction of Beclin1 expression in cardiac myocyte by RNAi reduces I/R-induced autophileagy and this is associated with enhanced cell survival.