C
Christopher D. Pfeiffer
Researcher at Oregon Health & Science University
Publications - 30
Citations - 2082
Christopher D. Pfeiffer is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Carbapenem-resistant enterobacteriaceae & Population. The author has an hindex of 10, co-authored 30 publications receiving 1902 citations. Previous affiliations of Christopher D. Pfeiffer include University of Wisconsin-Madison & Portland VA Medical Center.
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Journal ArticleDOI
Diagnosis of Invasive Aspergillosis Using a Galactomannan Assay: A Meta-Analysis
TL;DR: The galactomannan assay has moderate accuracy for diagnosis of invasive aspergillosis in immunocompromised patients and is more useful in patients who have hematological malignancy or who have undergone hematopoietic cell transplantation than in solid-organ transplant recipients.
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Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations
Barbara D. Alexander,Melissa D. Johnson,Christopher D. Pfeiffer,Cristina Jiménez-Ortigosa,Jelena Catania,Rachel Booker,Mariana Castanheira,Shawn A. Messer,David S. Perlin,Michael A. Pfaller +9 more
TL;DR: Echinocandin resistance is increasing, including among FLC-resistant isolates, and the importance of knowing the local epidemiology and resistance patterns for Candida within institutions and susceptibility testing of echinocands for C. glabrata to guide therapeutic decision making is underscored.
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Breakthrough Invasive Candidiasis in Patients on Micafungin
Christopher D. Pfeiffer,Guillermo Garcia-Effron,Aimee K. Zaas,John R. Perfect,David S. Perlin,Barbara D. Alexander +5 more
TL;DR: Whether the naturally occurring polymorphism within the C. parapsilosis FKS1 gene responsible for the bimodal wild-type MIC distribution is also responsible for micafungin MICs of >2 μg/ml and clinical breakthrough or an alternative mechanism contributes to the nonsusceptible echinocandin MICs in C. PARAPSilosis requires further study.
Journal ArticleDOI
Quantitation of Candida CFU in Initial Positive Blood Cultures
Christopher D. Pfeiffer,Gregory P. Samsa,Wiley A. Schell,L. Barth Reller,John R. Perfect,Barbara D. Alexander +5 more
TL;DR: Candida burden in the first positive blood culture of a BSI episode varies greatly; >50% of cultures had ≤1 CFU/ml, a concentration below the experimental yeast cell threshold for reliable DNA-based diagnostics.
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β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study.
Kimberly E. Hanson,Christopher D. Pfeiffer,Erika D. Lease,Alfred H. Balch,Aimee K. Zaas,John R. Perfect,Barbara D. Alexander +6 more
TL;DR: BDG monitoring may be useful for identifying ICU patients at highest risk to develop an IFI as well as for monitoring treatment response, and preemptive strategies based on fungal biomarkers warrant further study.