Melissa D. Johnson

TL;DR: A family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1, explaining why dectIn-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dect in human mucosal antifungal defense.

TL;DR: Echinocandin resistance is increasing, including among FLC-resistant isolates, and the importance of knowing the local epidemiology and resistance patterns for Candida within institutions and susceptibility testing of echinocands for C. glabrata to guide therapeutic decision making is underscored.

TL;DR: Treatment of invasive mycoses continues to be challenging and complicated by the net state of immunosuppression among infected hosts combined with relative lack of efficacy, significant toxicity, drug–drug interactions, and drug resistance associated with available antifungal agents.

TL;DR: Data indicate that CX3CR1-mediated renal resident macrophage survival is a critical innate mechanism of early fungal control that influences host survival in systemic candidiasis.

TL;DR: Findings indicate that the type I IFN pathway is a main signature of Candida-induced inflammation and plays a crucial role in anti-Candida host defense in humans.